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Catalog	name	Description	price
R-C-2225	Resveratrol (SRT501) CAS: 501-36-0	Resveratrol(SRT501,trans-Resveratrol)has a wide spectrum of targets including cyclooxygenases(COX,IC50=1.1μM),lipooxygenases（LOX,IC50=2.7μM),kinases, sirtuins and other proteins.It has anti-cancer,anti-inflammatory,blood-sugar-lowering and other beneficial cardiovascular effects.Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	price>
R-R-3925	Prenalterol CAS No.57526-81-5	Prenalterol/CAS No.57526-81-5 is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol can be used for researching cardiovascular disease.	price>
R-C-2226	Perifosine (KRX-0401)	Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity.Targeting cellular membranes,perifosine modulates membrane permeability,membrane lipid composition,phospholipid metabolism,and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.This agent also inhibits the anti-apoptotic mitogen-activated protein kinase(MAPK)pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase(SAPK/JNK)pathways,thereby inducing apoptosis.	price>
R-R-3926	Oxprenolol-d7 hydrochloride CAS No.1189649-47-5	Oxprenolol-d7 (hydrochloride)/CAS No.1189649-47-5 is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.	price>
R-C-2227	Rigosertib (ON-01910) CAS:592542-59-1	Rigosertib(ON-01910)is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9nM in a cell-free assay.It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals.Rigosertib induces apoptosis in various cancer cells.	price>
R-R-3927	AGN 192836 CAS No.171102-29-7	AGN 192836/CAS No.171102-29-7 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.	price>
R-C-2228	Lupenone CAS:1617-70-5	Lupenone,isolated from Rhizoma Musae,belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus,anti-diabetes,anti-cancer,improving Chagas disease without major toxicity.	price>
R-R-3928	Dopexamine hydrochloride CAS No.86484-91-5	Dopexamine hydrochloride/CAS No.86484-91-5 is a β2 adrenergic receptor agonist.	price>
R-C-2229	Solasodine CAS:126-17-0	Solasodine(Purapuridine,Solancarpidine,Solasodin,Salasodine,Salasdine)is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family.Solasodine reduces the mRNA level of matrix metalloproteinase-2(MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase(EMMPRIN),but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs(RECK).Solasodine downregulates oncogenic microRNA-21(miR-21),which has been known to target RECK.Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.	price>
R-R-3929	O-Desmethyl Mebeverine alcohol hydrochloride CAS No.856620-39-8	O-Desmethyl Mebeverine alcohol hydrochloride/CAS No.856620-39-8 is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.	price>
R-C-2230	Hispidulin CAS:1447-88-7	Hispidulin(Dinatin),an active natrual ingredient in a number of traditional Chinese medicinal herbs,exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71μM.Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells.Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.	price>
R-R-3930	(Rac)-Timolol-d5 maleate CAS No.1217260-21-3	Rac Timolol-d5 (maleate)/CAS No.1217260-21-3 is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction.	price>
R-C-2231	Trigonelline CAS： 535-83-1	Trigonelline,an alkaloid with potential antidiabetic activity,is present in considerable amounts in coffee.Trigonelline is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells.	price>
R-R-3931	Fenoterol-d6 hydrobromide CAS No.1286129-04-1	Fenoterol-d6 (hydrobromide) (Th-1165a-d6)/CAS No.1286129-04-1 is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.	price>
R-C-2232	Loureirin A CAS：119425-89-7	Loureirin A is a flavonoid extracted from Dragon is Blood,can inhibit Akt phosphorylation,and has antiplatelet activity.	price>
R-R-3932	Bufuralol-d9 hydrochloride CAS No.1173023-51-2	Bufuralol-d9 (hydrochloride)/CAS No.1173023-51-2 is the deuterium labeled Bufuralol hydrochloride.	price>
R-C-2233	AT7867 CAS：857531-00-1	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17nM/47nM and 85nM/20nM in cell-free assays,respectively;little activity outside the AGC kinase family.	price>
R-R-3933	Bisoprolol-d5 CAS No.1189881-87-5	Bisoprolol-d5/CAS No.1189881-87-5 is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.	price>
R-C-2234	Triciribine (NSC 154020) CAS:35943-35-2	Triciribine(VQD-002)is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity.Triciribine inhibits the phosphorylation,activation, and signalling of Akt-1,-2,and-3,which may result in the inhibition of Akt-expressing tumor cell proliferation.Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery,including Bcl-xL/Bcl-2-associated death promoter(BAD)and caspase 9.	price>
R-R-3934	Atomoxetine-d3 hydrochloride CAS No.1217776-38-9	Atomoxetine-d3 hydrochloride/CAS No.1217776-38-9 is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).	price>

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