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Catalog	name	Description	price
R-R-3852	(S)-Terazosin CAS No.109351-33-9	(S)-Terazosin/CAS No.109351-33-9 is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity α-adrenoceptor antagonist with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively.	price>
R-C-2153	UCB-9260 CAS:1515888-53-5	UCB-9260,an orally active compound,inhibits TNF signaling by stabilising an asymmetric form of the trimer.UCB-9260 is selective for TNF over other superfamily members,and binds TNF with a similar Kd of 13nM.	price>
R-R-3853	Amibegron hydrochloride CAS No.121524-09-2	Amibegron hydrochloride/CAS No.121524-09-2 is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.	price>
R-C-2154	Hypaphorine CAS:487-58-1	Hypaphorine is an indole-3-acetic acid antagonist which specifically compete with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases.Hypaphorine and endogenous indole-3-acetic acid counteract in controlling root hair elongation.	price>
R-R-3854	Lusaperidone CAS No.214548-46-6	Lusaperidone (R107474)/CAS No.214548-46-6 is an α2 adrenergic receptor antagonist with Kis of 0.13 and 0.15 nM for α2A and α2C, respectively.	price>
R-C-2155	Urolithin B CAS:1139-83-9	Urolithin B is a metabolite of the polyphenolic antioxidant ellagic acid that has diverse biological activities.It is formed from ellagic acid via several intermediates by gut microbiota.Urolithin B reduces the levels of advanced glycation end products(AGEs)in a cell-free assay in a concentration-dependent manner.Urolithin B(1.18-4.7nM)inhibits testosterone-induced proliferation of MCF-7aro cells.	price>
R-R-3855	ADRA1D receptor antagonist 1 CAS No.1191908-14-1	ADRA1D receptor antagonist 1/CAS No.1191908-14-1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.	price>
R-C-2156	Licochalcone D CAS:144506-15-0	Licochalcone D,a flavonoid compound mainly existing in the root of Glycyrrhiza inflate,is a potent inhibitor of NF-kappaB(NF-κB)p65.Licochalcone D possesses antioxidant,anti-inflammatory,anti-cancer properties.	price>
R-R-3856	Propranolol-d7 CAS No.98897-23-5	Propranolol-d7/CAS No.98897-23-5 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.	price>
R-C-2157	Licochalcone B CAS:58749-23-8	Licochalcone B has antitumor,antimetastatic,cardioprotective,antioxidant, antiapoptotic,and anti-inflammatory effects,it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride(CCl4)-induced injury,the protection may be due to inhibition of p38 and NFκB signaling,which subsequently reduces inflammation in the liver.	price>
R-R-3857	Aposcopolamine CAS No.535-26-2	Aposcopolamine/CAS No.535-26-2 is an alkaloid that can be isolated from Datura ferox. Aposcopolamin can closely binds with ACHE, ADRA2A and CHRM2. Aposcopolamine can be used for the research of Alzheimer disease.	price>
R-C-2158	Myrislignan CAS: 171485-39-5	Myrislignan has anti-inflammatory,and anti-cancer activities,it inhibited NF-κB signalling pathway activation,inhibited the proliferation of A549 cells in a dose-and time-dependent manner,it also significantly induced apoptosis and cell cycle arrest in A549 cells.	price>
R-R-3858	Tamsulosin hydrochloride CAS No.106463-17-6	Tamsulosin hydrochloride ((R)-(-)-YM12617)/CAS No.106463-17-6 is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-2159	E3330 CAS:136164-66-4	E3330(APX-3330)is a direct,orally active and selective AP endonuclease 1(APE1; REF-1)inhibitor,which suppresses NF-κB DNA-binding activity.E3330(APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330(APX-3330)shows anticancer properties,such as inhibition of cancer cell growth and migration.	price>
R-R-3859	Medroxalol CAS No.56290-94-9	Medroxalol (RMI81968)/CAS No.56290-94-9 is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.	price>
R-C-2160	Withaferin A CAS:5119-48-2	Withaferin A is a steroidal lactone present in W.somnifera that at 2-25μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts,causing apoptosis.	price>
R-R-3860	Bupranolol CAS No.14556-46-8	Bupranolol/CAS No.14556-46-8 is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity.	price>
R-C-2161	AZD7648 CAS:2230820-11-6	AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6nM in biochemical assay and more than 100-fold selective against 396 other kinases.	price>
R-R-3861	BMS-466442 CAS No.1598424-76-0	BMS-466442/CAS No.1598424-76-0 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research.	price>
R-C-2162	AZD1480 CAS:935666-88-9	AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2(JAK2)with potential antineoplastic activity.JAK2 inhibitor AZD1480 inhibits JAK2 activation,leading to the inhibition of the JAK/STAT(signal transducer and activator of transcription)signaling including activation of STAT3.	price>

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