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Catalog	name	Description	price
R-R-3896	Metoprolol-d7 hydrochloride CAS No.1219798-61-4	Metoprolol-d7 (hydrochloride)/CAS No.1219798-61-4 is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.	price>
R-C-2197	Dasatinib hydrochloride CAS:854001-07-3	Dasatinib(BMS-354825)hydrochloride is a highly potent,ATP competitive,orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity.The Kis are 16 pM and 30 pM for Src and Bcr-Abl,respectively.Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0nM and 0.5nM, respectively.Dasatinib hydrochloride also induces apoptosis and autophagy.	price>
R-C-2287	BC-1215 CAS:1507370-20-8	BC-1215 is an inhibitor of F-box protein 3(FBXO3,a ubiquitin E3 ligase component,IC50=0.9μg/mL for IL-1β release).BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination.BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215,interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC.	price>
R-R-3897	Prazosin-d8 CAS No.1006717-55-0	Prazosin-d8/CAS No.1006717-55-0 is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.	price>
R-C-2198	PD173955 CAS:260415-63-2	PD-173955 is a src tyrosine kinase inhibitor.PD173955 inhibited Bcr-Abl-dependent cell growth.PD173955 has an IC(50)of 1-2 nM in kinase inhibition assays of Bcr-Abl,and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation.PD173955 inhibited kit ligand-dependent c-kit autophosphorylation(IC(50)=approximately 25nM)and kit ligand-dependent proliferation of M07e cells(IC(50)=40nM)but had a lesser effect on interleukin 3-dependent(IC(50)=250nM)or granulocyte macrophage colony-stimulating factor (IC(50)=1 microM)-dependent cell growth.	price>
R-C-2288	THAL-SNS-032 CAS:2139287-33-3	THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon(CRBN).	price>
R-R-3898	Brombuterol-d9 CAS No.1353940-55-2	Brombuterol-d9/CAS No.1353940-55-2 is a deuterium labeled Brombuterol. Brombuterol is a β-adrenergic receptor agonist.	price>
R-C-2199	Asciminib (ABL001) CAS:1492952-76-7	Asciminib（ABL001）is a potent allosteric inhibitor of BCR-ABL.ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of chronic myeloid leukemia.Cell proliferation studies demonstrate that ABL001 selectively inhibited the growth of CML and Ph+ ALL cells with potencies ranging from 1-10nM range.	price>
R-C-2289	Apcin CAS:300815-04-7	Apcin(APC inhibitor)is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome(APC/C)that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.	price>
R-R-3899	Mibenratide CAS No.1239011-83-6	Mibenratide/CAS No.1239011-83-6, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research.	price>
R-C-2200	Berbamine CAS:478-61-5	Berbamine(BA),a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan),is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB,Berbamine(BA)induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).	price>
R-R-3900	Nadolol-d9 CAS No.94513-92-5	Nadolol-d9/CAS No.94513-92-5 is the deuterium labeled Nadolol. Nadolol is a non-selective and orally active β-adrenergic receptors blocker.	price>
R-C-2201	GMB-475 CAS:2490599-18-1	GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC,overcoming BCR-ABL1-dependent drug resistance.GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau(VHL),resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.	price>
R-R-3901	Clorprenaline CAS No.3811-25-4	Clorprenaline/CAS No.3811-25-4 is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive.	price>
R-C-2202	Ramucirumab (anti-VEGFR2) CAS:947687-13-0	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands:VEGF-A,VEGF-C,and VEGF-D.	price>
R-R-3902	Salmeterol-d3 CAS No.497063-94-2	Salmeterol-d3/CAS No.497063-94-2 is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.	price>
R-C-2203	Sulfatinib CAS:1308672-74-3	Sulfatinib(HMPL-012)is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3,FGFR1 and CSF1R with IC50s of in a range of 1 to 24nM.	price>
R-R-3903	Guanoxabenz hydrochloride CAS No.23256-40-8	Guanoxabenz (Hydroxyguanabenz) hydrochloride/CAS No.23256-40-8 is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor.	price>
R-C-2204	Taxifolin (Dihydroquercetin) CAS:480-18-2	Taxifolin((+)-Dihydroquercetin)exhibits important anti-tyrosinase activity.Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3μM.Taxifolin is an important natural compound with antifibrotic activity.Taxifolin is a free radical scavenger with antioxidant capacity.	price>
R-R-3904	Arbutamine CAS No.128470-16-6	Arbutamine/CAS No.128470-16-6 is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent .	price>

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