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Catalog	name	Description	price
R-R-3791	Atenolol-d7 CAS No.1202864-50-3	Atenolol-d7/CAS No.1202864-50-3 is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.	price>
R-C-2092	Resatorvid (TAK-242) CAS：243984-11-4	Resatorvid(TAK-242,CLI-095)is a small-molecule-specific inhibitor of Toll-like receptor(TLR)4 signaling,blocking LPS-induced production of NO,TNF-α and IL-6 in macrophages with IC50 of 1.8nM,1.9nM and 1.3nM,respectively.Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.	price>
R-R-3792	Bretylium tosylate CAS No.61-75-6	Bretylium (tosylate)/CAS No.61-75-6 is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters.	price>
R-R-3793	Etilefrine hydrochloride CAS No.943-17-9	Etilefrine hydrochloride/CAS No.943-17-9 is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension.	price>
R-C-2094	PF06869206 CAS：2227425-05-8	PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a(SLC34A1)with an IC50 of 380nM.	price>
R-R-3794	CGP 20712 A CAS No.105737-62-0	CGP 20712 A (CGP 20712 mesylate)/CAS No.105737-62-0 is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.	price>
R-C-2095	BI-409306 CAS：1189767-28-9	BI 409306(SUB 166499)is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM,respectively.Treatment with BI 409306 increases brain cGMP levels,promotes long-term potentiation,and improves episodic and working memory performance in rodents.	price>
R-R-3795	ONO-2952 CAS No.895169-20-7	ONO-2952/CAS No.895169-20-7 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment.	price>
R-C-2096	ONO-8590580 CAS：1802661-73-9	ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.	price>
R-R-3796	Centanafadine hydrochloride CAS No.923981-14-0	Centanafadine (hydrochloride)/CAS No.923981-14-0 is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.	price>
R-C-2097	UCB9608 CAS：1616413-96-7	UCB9608 is a potent,selective and orally active PI4KIIIβ inhibitor,with an IC50 of 11 nM,selective over PI3KC2 α,β,and γ lipid kinases.UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent.	price>
R-R-3797	Vanilpyruvic acid CAS No.1081-71-6	Vanilpyruvic acid/CAS No.1081-71-6 is a catecholamine metabolite and precursor to vanillactic acid.	price>
R-C-2098	fulacimstat(BAY1142524) CAS： 1488354-15-9	Fulacimstat is an orally available chymase inhibitor,with IC50s of 4,3nM for human and hamster chymase enzyme,respectively.	price>
R-R-3798	Clorprenaline hydrochloride CAS No.6933-90-0	Clorprenaline hydrochloride/CAS No.6933-90-0 is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research.	price>
R-C-2099	(-)-(S)-B973B CAS：2244989-34-0	(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR,with antinociceptive activity.	price>
R-R-3799	Guanadrel CAS No.40580-59-4	Guanadrel/CAS No.40580-59-4 is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies.	price>
R-C-2100	CT-1812 CAS：1802632-22-9	CT-1812 is a first-in-class,orally available sigma-2/PGRMC1 antagonist(alpha beta oligomer receptor antagonist),is being developed by Cognition.sCT-1812 is a novel therapeutic candidate for Alzheimer is disease.	price>
R-R-3800	LY377604 CAS No.204592-94-9	LY377604/CAS No.204592-94-9 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.	price>
R-C-2101	BAY-545 CAS：1699717-32-2	BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66,400,280 nM for human, mouse,rat A2B adenosine receptor in cells,respectively,and a Ki of 97nM for human A2B adenosine receptor,with more selectivity over A1,A2A,and A3 adenosine receptor.	price>
R-R-3801	Apraclonidine hydrochloride CAS No.73218-79-8	Apraclonidine hydrochloride (ALO 2145)/CAS No.73218-79-8, a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.	price>

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