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Catalog	name	Description	price
R-R-3856	Propranolol-d7 CAS No.98897-23-5	Propranolol-d7/CAS No.98897-23-5 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.	price>
R-C-2157	Licochalcone B CAS:58749-23-8	Licochalcone B has antitumor,antimetastatic,cardioprotective,antioxidant, antiapoptotic,and anti-inflammatory effects,it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride(CCl4)-induced injury,the protection may be due to inhibition of p38 and NFκB signaling,which subsequently reduces inflammation in the liver.	price>
R-R-3857	Aposcopolamine CAS No.535-26-2	Aposcopolamine/CAS No.535-26-2 is an alkaloid that can be isolated from Datura ferox. Aposcopolamin can closely binds with ACHE, ADRA2A and CHRM2. Aposcopolamine can be used for the research of Alzheimer disease.	price>
R-C-2158	Myrislignan CAS: 171485-39-5	Myrislignan has anti-inflammatory,and anti-cancer activities,it inhibited NF-κB signalling pathway activation,inhibited the proliferation of A549 cells in a dose-and time-dependent manner,it also significantly induced apoptosis and cell cycle arrest in A549 cells.	price>
R-R-3858	Tamsulosin hydrochloride CAS No.106463-17-6	Tamsulosin hydrochloride ((R)-(-)-YM12617)/CAS No.106463-17-6 is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-2159	E3330 CAS:136164-66-4	E3330(APX-3330)is a direct,orally active and selective AP endonuclease 1(APE1; REF-1)inhibitor,which suppresses NF-κB DNA-binding activity.E3330(APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330(APX-3330)shows anticancer properties,such as inhibition of cancer cell growth and migration.	price>
R-R-3859	Medroxalol CAS No.56290-94-9	Medroxalol (RMI81968)/CAS No.56290-94-9 is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.	price>
R-C-2160	Withaferin A CAS:5119-48-2	Withaferin A is a steroidal lactone present in W.somnifera that at 2-25μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts,causing apoptosis.	price>
R-R-3860	Bupranolol CAS No.14556-46-8	Bupranolol/CAS No.14556-46-8 is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity.	price>
R-C-2161	AZD7648 CAS:2230820-11-6	AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6nM in biochemical assay and more than 100-fold selective against 396 other kinases.	price>
R-R-3861	BMS-466442 CAS No.1598424-76-0	BMS-466442/CAS No.1598424-76-0 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research.	price>
R-C-2162	AZD1480 CAS:935666-88-9	AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2(JAK2)with potential antineoplastic activity.JAK2 inhibitor AZD1480 inhibits JAK2 activation,leading to the inhibition of the JAK/STAT(signal transducer and activator of transcription)signaling including activation of STAT3.	price>
R-R-3862	Desglymidodrine CAS No.3600-87-1	Desglymidodrine (ST 1059)/CAS No.3600-87-1, the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure.	price>
R-C-2163	Linderalactone CAS:728-61-0	Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins(Bax and Bcl-2)with an IC50 of 15µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway.	price>
R-R-3863	Metipranolol hydrochloride CAS No.36592-77-5	Metipranolol hydrochloride/CAS No.36592-77-5 is a non-selective β adrenergic receptor blocking agent.	price>
R-C-2164	PF-06826647 CAS:2127109-84-4	PF-06826647 is an orally active and selective TYK2 inhibitor(IC50=17nM),which binds to TYK2 catalytically active JH1 domain.PF-06826647 displays selectivity for TYK2 over JAK1(IC50=383nM)and JAK2(74nM).PF-06826647 can be used for the research of psoriasis,ulcerative colitis, and hidradenitis suppurativa.	price>
R-R-3864	Dicentrine CAS No.517-66-8	Dicentrine/CAS No.517-66-8 is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates.	price>
R-C-2165	TG101209 CAS:936091-14-4	TG101209 is a selective JAK2 inhibitor with IC50 of 6nM, less potent to Flt3 and RET(c-RET)with IC50 of 25 nM and 17nM in cell-free assays,~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.	price>
R-R-3865	HOKU-81 CAS No.58020-43-2	HOKU-81 (4-Hydroxytulobuterol)/CAS No.58020-43-2 is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect.	price>
R-C-2166	Upadacitinib (ABT-494) CAS:1310726-60-3	Upadacitinib（ABT-494)is a potent and selective JAK inhibitors in development for rheumatoid arthritis.ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific,relevant cytokines.ABT-494 demonstrates efficacy in rat arthritis models.	price>

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