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Catalog	name	Description	price
R-R-3612	Rauwolscine hydrochloride CAS No.6211-32-1	Rauwolscine hydrochloride/CAS No.6211-32-1 is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.	price>
R-C-1913	LY3200882 CAS： 1898283-02-7	LY 3200882 is a potent,highly selective inhibitor of TGF-β receptor type 1(TGFβRI).It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.	price>
R-R-3613	Acebutolol hydrochloride CAS No.34381-68-5	Acebutolol hydrochloride/CAS No.34381-68-5 is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.	price>
R-C-1914	LY2795050 CAS：1346133-08-1	LY2795050 is a novel selective κ-opioid Receptor(KOR)antagonist(IC50=0.72nM) and has the potential as a PET tracer to image KOR in vivo.	price>
R-R-3614	Midodrine hydrochloride CAS No.43218-56-0	Midodrine hydrochloride ((±)-Midodrine hydrochloride)/CAS No.43218-56-0 is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.	price>
R-C-1915	DWK-1339 CAS：1018946-38-7	MDR-1339(DWK-1339)is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor,used in the research of Alzheimer is disease.	price>
R-R-3615	Penbutolol sulfate CAS No.38363-32-5	Penbutolol sulfate/CAS No.38363-32-5 is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker.	price>
R-C-1916	Itanapraced (CHF 5074) CAS:749269-83-8	Itanapraced(CHF 5074,CSP-1103)is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion.The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100μmol/L.	price>
R-R-3616	JP1302 dihydrochloride CAS No.1259314-65-2	JP1302 dihydrochloride/CAS No.1259314-65-2 is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research.	price>
R-C-1917	Pralsetinib (BLU-667) CAS:2097132-94-8	Pralsetinib(BLU-667,CS 3009,Gavreto)is a highly potent and selective RET (c-RET)inhibitor with an IC50 of 0.4 nM for WT RET.It also demonstrates potent activity(IC50 0.4 nmol/L)against common oncogenic RET alterations,including RET(M918T).	price>
R-R-3617	Medetomidine hydrochloride CAS No.86347-15-1	Medetomidine hydrochloride/CAS No.86347-15-1 is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels.	price>
R-C-1918	SKL 2001 CAS:909089-13-0	SKL2001 is an agonist of the Wnt/β-catenin pathway,with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.	price>
R-R-3618	2-Methoxyidazoxan monohydrochloride CAS No.109544-45-8	2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride)/CAS No.109544-45-8 is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2).	price>
R-C-1919	PJ34 CAS: 344458-19-1	PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110nM and 86nM, respectively.	price>
R-R-3619	(R)-Carvedilol CAS No.95093-99-5	(R)-Carvedilol ((R)-BM 14190)/CAS No.95093-99-5, the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).	price>
R-C-1920	JNJ-632 CAS: 1572510-42-9	JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D.Administration of JNJ-632 in HBV genotype D infected chimeric mice,resulted in a 2.77 log reduction of the HBV DNA viral load.	price>
R-R-3620	Lubabegron CAS No.391920-32-4	Lubabegron/CAS No.391920-32-4 is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste.	price>
R-C-1921	ASK1-IN-1 CAS:2411382-24-4	ASK1-IN-1 is a CNS-penetrant ASK1(apoptosis signal-regulating kinase 1) inhibitor,with good potency(cell IC50=138nM;Biochemical IC50=21nM).	price>
R-R-3621	Prazosin CAS No.19216-56-9	Prazosin/CAS No.19216-56-9 is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.	price>
R-C-1922	Cabazitaxel（XRP6258） CAS:183133-96-2	Cabazitaxel(RPR-116258A,XRP6258,TXD 258,Taxoid XRP6258)is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth.Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly,processes that are essential for cells to divide.Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.	price>

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