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Catalog	name	Description	price
R-C-2263	BSJ-4-116 CAS：2519823-34-6	BSJ-4-116 is a highly potent and selective CDK12 degrader(PROTAC)with an IC50 of 6 nM.BSJ-4-116 downregulates DDR genes through a premature termination of transcription,primarily through increasing poly(adenylation).BSJ-4-116 exhibits potent antiproliferative effects,alone and in combination with the poly(ADP-ribose)polymerase inhibitor Olaparib(HY-10162).	price>
R-R-3603	Guanabenz hydrochloride CAS No.23113-43-1	Guanabenz hydrochloride/CAS No.23113-43-1 is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.	price>
R-C-1904	M2I-1 CAS：312271-03-7	M2I-1 is an inhibitor of Mad2(mitotic arrest deficient 2)targeting the binding of Mad2 to Cdc20,an essential protein-protein interaction(PPI)within the SAC(spindle assembly checkpoint).	price>
R-C-2264	CC-671 CAS：1618658-88-0	CC-671 is a dual TTK protein kinase/CDC2-like kinase(CLK2)inhibitor with IC50s of 0.005 and 0.006μM for TTK and CLK2,respectively.	price>
R-R-3604	BI-167107 CAS No.1202235-68-4	BI-167107/CAS No.1202235-68-4 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM.	price>
R-C-1905	BAG956 CAS：853910-02-8	BAG 956,also known as NVP-BAG956,is a dual PDK1 and class I PI 3-kinase inhibitor.BAG 956 has been shown to inhibit cellular AKT phosphorylation at Thr308.BAG 956 also blocks cell proliferation and causes arrest in the G1 phase of the cell cycle.BAG 956 has been shown to slow tumor progression in mouse xenograft models.	price>
R-R-3605	Reboxetine mesylate CAS No.98769-84-7	Reboxetine mesylate (FCE20124 mesylate)/CAS No.98769-84-7 is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM.	price>
R-C-1906	KO-947 CAS：1695533-89-1	KO-947 is a potent and selective inhibitor of ERK1/2 kinases.KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations.	price>
R-R-3606	Idazoxan hydrochloride CAS No.79944-56-2	Idazoxan hydrochloride (RX 781094 hydrochloride)/CAS No.79944-56-2 is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs).	price>
R-C-1907	ARN-3236 CAS：1613710-01-2	ARN-3236 is potent,orally active and selective SIK2 inhibitor.ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6μmol/L.	price>
R-R-3607	Vibegron CAS No.1190389-15-1	Vibegron (MK-4618)/CAS No.1190389-15-1 is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder.	price>
R-C-1908	SAR-20347 CAS：1450881-55-6	SAR-20347 is a potent inhibitor of TYK2,JAK1,JAK2 and JAK3 with IC50 of 0.6 nM,23nM,26nM and 41nM,respectively.SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.	price>
R-R-3608	DL-Norepinephrine hydrochloride CAS No.55-27-6	DL-Norepinephrine hydrochloride/CAS No.55-27-6 is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension.	price>
R-C-1909	AD 80 CAS：1384071-99-1	AD80,a multikinase inhibitor,shows strong activity against human RET(c-RET),BRAF,S6K,and SRC but were much less active than either AD57 or AD58 against mTOR.The IC50 value for RET is 4nM.	price>
R-R-3609	Indacaterol maleate CAS No.753498-25-8	Indacaterol maleate (QAB149)/CAS No.753498-25-8 is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research.	price>
R-C-1910	Cerdulatinib CAS：1198300-79-6	Cerdulatinib(PRT-062070)is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12nM/6nM/8 nM/0.5nM and 32nM for JAK1/JAK2/JAK3/TYK2 and Syk.	price>
R-R-3610	Vilanterol CAS No.503068-34-6	Vilanterol (GW642444)/CAS No.503068-34-6 is a long-acting β2-adrenoceptor (β2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.	price>
R-C-1911	Tomivosertib (eFT-508) CAS：1849590-01-7	Tomivosertib(eFT-508)is a potent and selective MNK1/2 inhibitor with IC50s of 2.4nM and 1 nM,respectively.It potentially results in decreased tumor cell proliferation and tumor growth.Tomivosertib(eFT-508)inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	price>
R-R-3611	(R)-Propranolol hydrochloride CAS No.13071-11-9	(R)-Propranolol hydrochloride/CAS No.13071-11-9 is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.	price>
R-C-1912	SM164 CAS：957135-43-2	SM-164 is a potent,non-peptide,cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39nM.SM-164 induces apoptosis and tumor regression.	price>

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