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Catalog	name	Description	price
R-R-3596	Tamsulosin CAS No.106133-20-4	Tamsulosin ((R)-(-)-YM12617 free base)/CAS No.106133-20-4 is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-1897	Valbenazine CAS:1025504-45-3	Valbenazine（NBI-98854 and MT-5199)is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication,while at the same time having minimal impact on the other monoamines.NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients.These results support the phase 3 clinical trials of NBI-98854 now underway.	price>
R-C-2257	Alobresib (GS-5829) CAS：1637771-14-2	Alobresib(GS-5829)is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc.Alobresib(GS-5829)inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways,such as BLK,AKT,ERK1/2,and MYC.Alobresib (GS-5829)also inhibits NF-κB signaling.	price>
R-R-3597	SR59230A hydrochloride CAS No.1135278-41-9	SR59230A hydrochloride/CAS No.1135278-41-9 is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.	price>
R-C-1898	AS703026 CAS：1236699-92-5	AS703026 is a novel,selective,orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.	price>
R-C-2258	Ailanthone CAS：981-15-7	Ailanthone(AIL,Δ13-Dehydrochaparrinone),a natural anti-hepatocellular carcinoma (HCC)component in Ailanthus altissima,induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27.Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway.Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells.	price>
R-R-3598	Guanfacine hydrochloride CAS No.29110-48-3	Guanfacine hydrochloride/CAS No.29110-48-3 is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette syndrome and attention deficit hyperactivity disorder (ADHD).	price>
R-C-1899	C188-9 CAS：432001-19-9	C188-9(TTI 101)is a potent inhibitor of STAT3 that binds to STAT3 with high affinity(KD=4.7±0.4nM).C188-9 is well tolerated in mice,shows good oral bioavailability,and is concentrated in tumors.	price>
R-C-2259	Methyl-Hesperidin CAS：11013-97-1	Methyl Hesperidin is a flavanone glycoside(flavonoid)(C28H34O15)found abundantly in citrus fruits.Its aglycone form is called hesperetin.	price>
R-R-3599	L748337 CAS No.244192-94-7	L748337/CAS No.244192-94-7 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.	price>
R-C-1900	BD1063 HCl CAS：206996-13-6	BD1063 2HCL(BD1063 dihydrochloride)is a potent and selective sigma-1 receptor (σ1R)antagonist with Ki of 4.43nM.	price>
R-C-2260	Dinaciclib (SCH727965) CAS：779353-01-4	Dinaciclib(SCH727965,PS-095760)is a novel and potent CDK inhibitor for CDK2,CDK5,CDK1 and CDK9 with IC50 of 1nM,1nM,3nM and 4nM in cell-free assays,respectively.It also blocks thymidine(dThd)DNA incorporation.Dinaciclib induces apoptosis through the activation of caspases 8 and 9.	price>
R-R-3600	Atipamezole hydrochloride CAS No.104075-48-1	Atipamezole (MPV-1248) hydrochloride/CAS No.104075-48-1 is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.	price>
R-C-1901	SF 2523 CAS：1174428-47-7	SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM,158nM,9nM,241nM and 280nM for PI3Kα,PI3Kγ,DNA-PK,BRD4 and mTOR, respectively.	price>
R-C-2261	Flavopiridol (L86-8275) CAS：146426-40-6	Flavopiridol(L86-8275,Alvocidib,NSC 649890,HMR-1275)competes with ATP to inhibit CDKs including CDK1,CDK2,CDK4,CDK6,and CDK9 with IC50 values in the 20-100nM range.It is more selective for CDK1,2,4,6,9 versus CDK7.Flavopiridol is initially found to inhibit EGFR and PKA.Flavopiridol induces autophagy and ER stress.Flavopiridol blocks HIV-1 replication.	price>
R-R-3601	Pronethalol CAS No.54-80-8	Pronethalol ((±)-Pronethalo)/CAS No.54-80-8 is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).	price>
R-C-1902	Monastrol CAS：329689-23-8	Monastrol((±)-Monastrol)is a cell-permeable small molecule inhibitor of kinesin-5(KIF11)which is essential for maintaining separation of the half-spindles.	price>
R-C-2262	LY3405105 CAS：2326428-25-3	LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8nM.LY3405105 shows potential antineoplastic activity.	price>
R-R-3602	Metoprolol succinate CAS No.98418-47-4	Metoprolol succinate/CAS No.98418-47-4 is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.	price>
R-C-1903	TC-G-1008 (GPR39-C3) CAS：1621175-65-2	TC-G-1008 is a GPR39(zinc receptor)agonist(EC50 values are 0.4 and 0.8nM for rat and human receptors respectively).	price>

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