Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-3569	KI-7 CAS No.1489263-00-4	KI-7/CAS No.1489263-00-4 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively.	price>
R-C-1870	DDP-38003 dihydrochloride CAS:1831167-98-6	DDP-38003 dihydrochloride is an novel,orally available inhibitor of histone lysine-specific demethylase 1A(KDM1A/LSD1)with an IC50 of 84nM.	price>
R-R-3570	Doxofylline-d6 CAS No.1219805-99-8	Doxofylline-d6/CAS No.1219805-99-8 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.	price>
R-C-1871	Tropifexor (LJN452) CAS:1383816-29-2	Tropifexor(LJN452)is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay.It shows no significant off-target activity against a broad panel of enzyme,ion channel,nuclear receptor,and GPCR(>10000-fold selectivity for FXR).	price>
R-R-3571	LUF6096 CAS No.1116652-18-6	LUF6096/CAS No.1116652-18-6, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury.	price>
R-C-1872	JNJ7706621 CAS:443797-96-4	JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays.It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.	price>
R-R-3572	Theobromine-d3 CAS No.65566-69-0	Theobromine-d3/CAS No.65566-69-0 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.	price>
R-C-1873	Mc-MMAE CAS:863971-24-8	Mc-MMAE is a protective group(maleimidocaproyl)-conjugated monomethyl auristatin E(MMAE),which is a potent tubulin inhibitor.Mc-MMAE is a drug-linker conjugate for ADC.	price>
R-R-3573	KFM19 CAS No.133058-72-7	KFM19/CAS No.133058-72-7 is a potent, selective Adenosine receptor (A1-receptor) antagonist, with an IC50 of 50 nM.	price>
R-C-1874	IPI3063 CAS:1425043-73-7	IPI-3063 is a Selective Phosphoinoside-3-Kinase p110δInhibitor.IPI-3063 Potently Suppresses B Cell Survival,Proliferation,and Differentiation.IPI-3063 is a highly potent molecule useful for studying p110δ function in immune cells.	price>
R-R-3574	PSB-1115 CAS No.152529-79-8	PSB-1115/CAS No.152529-79-8 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).	price>
R-C-1875	BAM7 CAS:331244-89-4	BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3μM.	price>
R-R-3575	GP531 CAS No.142344-87-4	GP531/CAS No.142344-87-4 is a potent, second-generation adenosine regulating agent, is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.	price>
R-C-1876	BTSA 1 CAS:314761-14-3	BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.	price>
R-R-3576	Adenosine receptor antagonist 3 CAS No.2400864-80-2	Adenosine receptor antagonist 3/CAS No.2400864-80-2 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1).	price>
R-C-1877	Ziritaxestat (GLPG1690) CAS:1628260-79-6	Ziritaxestat(GLPG1690)is a first-in-class autotaxin(ATX)inhibitor,with an IC50 of 131 nM and Ki of 15nnM.	price>
R-R-3577	Inupadenant hydrochloride CAS No.2411004-22-1	Inupadenant (EOS-850) hydrochloride/CAS No.2411004-22-1 is an orally active, highly selective A2A receptor antagonist. Inupadenant hydrochloride is not brain-penetrant. Inupadenant hydrochloride has potent anti-tumor activity.	price>
R-C-1878	AZD-7594 CAS:1196509-60-0	AZD-7594(AZ13189620)is an inhaled selective glucocorticoid receptor(GCCR)modulator.AZD-7594 is in phase II clinical trials by AstraZeneca for the treatment of mild to moderate asthma.It is also in phase I clinical trials for the treatment of chronic obstructive pulmonary disorder(COPD).	price>
R-R-3578	Sipagladenant CAS No.858979-50-7	Sipagladenant (Compound I)/CAS No.858979-50-7 is an orally active adenosine receptor A2A inverse agonist. Sipagladenant can be used in frontal lobe dysfunction research.	price>
R-C-1879	KPT9274 CAS:1643913-93-2	KPT 9274(ATG-019)is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT.It shows an IC50 of~120nM for NAMPT in a cell-free enzymatic assay.	price>

562563564565566567 568569570571572