Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-3556	8-Cyclopentyl-1,3-dimethylxanthine CAS No.35873-49-5	8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a)/CAS No.35873-49-5 is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.	price>
R-C-1857	FM-381 CAS:2226521-65-7	FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909.FM-381 has an IC50 of 127 pM for JAK3,with 410,2700 and 3600-fold selectivity over JAK1,JAK2 and TYK2,respectively.	price>
R-R-3557	Norisoboldine CAS No.23599-69-1	Norisoboldine/CAS No.23599-69-1 is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.	price>
R-C-1858	Bafetinib (INNO-406) CAS:859212-16-1	Bafetinib(INNO-406,NS-187)is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8nM/19nM in cell-free assays,does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.	price>
R-R-3558	Cirazoline hydrochloride CAS No.40600-13-3	Cirazoline hydrochloride (LD 3098 hydrochloride)/CAS No.40600-13-3 is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).	price>
R-C-1859	IOX4 CAS:1154097-71-8	IOX4 is a selective HIF prolyl-hydroxylase 2(PHD2)inhibitor with an IC50 value of 1.6nM,induces HIFα in cells and in wildtype mice with marked induction in the brain tissue.IOX4 competes with and displaces 2-oxoglutarate(2OG)at the active site of PHD2.	price>
R-R-3559	MRS-3777 hemioxalate CAS No.1186195-57-2	MRS-3777 hemioxalate/CAS No.1186195-57-2 is a selective adenosine A3 receptor antagonist.	price>
R-C-1860	Autophinib CAS:1644443-47-9	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.The IC50 value for Vps34 is 19nM in vitro.	price>
R-R-3560	Adenosine receptor antagonist 2 CAS No.2703054-47-9	Adenosine receptor antagonist 2/CAS No.2703054-47-9 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.	price>
R-C-1861	SGI-1776 CAS:1025065-69-3	SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity.Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1,-2 and -3,serine-threonine kinases,which may result in the interruption of the G1/S phase cell cycle transition,the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis.PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.	price>
R-R-3561	Adenosine A1 receptor activator T62 CAS No.40312-34-3	Adenosine A1 receptor activator T62/CAS No.40312-34-3 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.	price>
R-C-1862	NG25 CAS:1315355-93-1	NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1.It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK,FER,and p38.NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells.It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097,respectively.NG 25 decreases cell viability of HCT116KRASWT,and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.	price>
R-R-3562	Tecadenoson CAS No.204512-90-3	Tecadenoson (CVT-510)/CAS No.204512-90-3 is a selective A1 adenosine receptor agonist.	price>
R-C-1863	Vecabrutinib (SNS-062) CAS:1510829-06-7	Vecabrutinib(SNS-062)is a potent,noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2nM,respectively.Vecabrutinib shows an IC50 of 24 nM for ITK.	price>
R-R-3563	CV1808 CAS No.53296-10-9	CV1808 (2-Phenylaminoadenosine)/CAS No.53296-10-9 is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.	price>
R-C-1864	BAY 61-3606 CAS:732983-37-8	BAY 61-3606 is an orally available,ATP-competitive,reversible and highly selective Syk inhibitor with a Ki of 7.5nM and an IC50 of 10nM.BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell.BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates.Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.	price>
R-R-3564	FR194921 CAS No.202646-80-8	FR194921/CAS No.202646-80-8 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with Ki value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity.	price>
R-C-1865	Takinib CAS:1111556-37-6	Takinib(EDHS-206)is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM,more than 1.5 log more potent than the second and third ranked targets,IRAK4(120 nM)and IRAK1(390 nM),respectively.Takinib induces apoptosis.	price>
R-R-3565	HEMADO CAS No.403842-38-6	HEMADO/CAS No.403842-38-6 is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1866	BAY1895344 CAS:1876467-74-1	Elimusertib(BAY-1895344)is a very potent and highly selective ATR(ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7nM Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78nM.	price>

561562563564565566 567568569570571