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Catalog	name	Description	price
R-R-3549	Theophylline-d6 CAS No.117490-39-8	Theophylline-d6/CAS No.117490-39-8 is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.	price>
R-C-1850	CG347B CAS:1598426-03-9	CG347B is a selective inhibitor of HDAC6.	price>
R-R-3550	LUF6000 CAS No.890087-21-5	LUF6000/CAS No.890087-21-5 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect.	price>
R-C-1851	Tinostamustine(EDO-S101) CAS:1236199-60-2	EDO-S101(Tinostamustine)is a pan HDAC inhibitor; inhibits HDAC6,HDAC1,HDAC2 and HDAC3 with IC50 values of 6nM,9nM,9nM and 25nM,respectively.	price>
R-R-3551	A2B receptor antagonist 2 CAS No.784-90-7	A2B receptor antagonist 2 (compound 18)/CAS No.784-90-7 is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively.	price>
R-C-1852	TP-4748 CAS:1150114-62-7	TP-4748 is a biochemical.	price>
R-R-3552	PSB 0777 ammonium hydrate	PSB 0777 ammonium hydrate is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium hydrate has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium hydrate shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium hydrate has the potential for inflammatory bowel disease (IBS) research research.	price>
R-C-1853	DBPR114 CAS：2443767-35-7	DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases,including Aurora-A,FLT3,CSF1R,MET,etc.DBPR114 exhibited favorable PK profiles:a long half-life(t1/2 =23.5h),moderate clearance and high volume of distribution.Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11,MIA PaCa-2,Hep3B, MKN45,Colo205,and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.	price>
R-R-3553	ANR94 CAS No.634924-89-3	ANR94/CAS No.634924-89-3 is a potent and selective adenosine A2A receptor (AA2AR) antagonist with an Ki of 46 nM for hAA2AR. ANR94 has the potential for the research of Parkinson disease.	price>
R-C-1854	TP748 CAS:951698-15-0	TP748 is a bioactive chemical.	price>
R-R-3554	Xanthine amine congener hydrochloride CAS No.1783977-95-6	Xanthine amine congener (XAC) hydrochloride/CAS No.1783977-95-6 is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.	price>
R-C-1855	THZ2 CAS:1604810-84-5	THZ2,a THZ1 analog,is a selective inhibitor of CDK7 with IC50 of 13.9 nM.THZ2 efficiently suppresses the clonogenic growth of TNBC cells with IC50 of ~10nM.	price>
R-R-3555	MRS1334 CAS No.192053-05-7	MRS1334/CAS No.192053-05-7 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1856	THZ531 CAS:1702809-17-3	THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM.	price>
R-R-3556	8-Cyclopentyl-1,3-dimethylxanthine CAS No.35873-49-5	8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a)/CAS No.35873-49-5 is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.	price>
R-C-1857	FM-381 CAS:2226521-65-7	FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909.FM-381 has an IC50 of 127 pM for JAK3,with 410,2700 and 3600-fold selectivity over JAK1,JAK2 and TYK2,respectively.	price>
R-R-3557	Norisoboldine CAS No.23599-69-1	Norisoboldine/CAS No.23599-69-1 is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.	price>
R-C-1858	Bafetinib (INNO-406) CAS:859212-16-1	Bafetinib(INNO-406,NS-187)is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8nM/19nM in cell-free assays,does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.	price>
R-R-3558	Cirazoline hydrochloride CAS No.40600-13-3	Cirazoline hydrochloride (LD 3098 hydrochloride)/CAS No.40600-13-3 is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).	price>
R-C-1859	IOX4 CAS:1154097-71-8	IOX4 is a selective HIF prolyl-hydroxylase 2(PHD2)inhibitor with an IC50 value of 1.6nM,induces HIFα in cells and in wildtype mice with marked induction in the brain tissue.IOX4 competes with and displaces 2-oxoglutarate(2OG)at the active site of PHD2.	price>

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