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Catalog	name	Description	price
R-R-3421	Perphenazine-d4 CAS No.155593-75-2	Perphenazine-d4/CAS No.155593-75-2 is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.	price>
R-C-1722	PD-166866 CAS:192705-79-6	PD166866 is a FGFR1 inhibitor with IC50 value of 55 nM,and no effect on c-Src, PDGFR-b,EGFR or insulin receptor tyrosine kinases or MEK,PKC,and CDK4.	price>
R-R-3422	3-Hydroxy agomelatine-d3 CAS No.1079774-23-4	3-Hydroxy agomelatine-d3/CAS No.1079774-23-4 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>
R-C-1723	AZD9496 CAS:1639042-08-2	AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.	price>
R-R-3423	Eplivanserin (mixture) CAS No.130581-13-4	Eplivanserin mixture (SR-46349 mixture)/CAS No.130581-13-4 is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1.	price>
R-C-1724	Dastroline(Epinastine) CAS: 80012-43-7	Emedastine is a potent,high affinity histamine H1-receptor-selective antagonist with Ki of 1.3±0.1nM for H1-receptors while considerably weaker at H2-(K1=49,067±11,113nM) and H3-receptors(Ki=12,430±1,282nM).	price>
R-R-3424	3-AQC CAS No.201216-42-4	3-AQC/CAS No.201216-42-4, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist.	price>
R-C-1725	Peficitinib CAS: 944118-01-8	Peficitinib is a novel potent JAK inhibitor,which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.	price>
R-R-3425	Ondansetron-13C,d3 CAS No.2699607-85-5	Ondansetron-13C,d3/CAS No.2699607-85-5 is the 13C- and deuterium labeled Ondansetron.	price>
R-C-1726	Vemurafenib (PLX4032) CAS:918504-65-1	Vemurafenib(PLX4032,RG7204,RO5185426)is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay.10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold.Vemurafenib(PLX4032,RG7204)induces autophagy.	price>
R-R-3426	Brexpiprazole-d8 CAS No.1427049-21-5	Brexpiprazole-d8/CAS No.1427049-21-5 is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM).	price>
R-C-1727	Boceprevir (SCH-503034) CAS:394730-60-0	Boceprevir(EBP 520)is a potent, highly selective,orally bioavailable HCV NS3 protease inhibitor with a Ki of 14nM in both enzyme assay and an EC90 of 350nM in cell-based replicon assay.Boceprevir inhibits SARS-CoV-2 3CLpro activity.	price>
R-R-3427	Agomelatin-d3 CAS No.1079389-38-0	Agomelatin-d3/CAS No.1079389-38-0 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.	price>
R-C-1728	Doxorubicin (Adriamycin) HCl CAS:25316-40-9	Doxorubicin(Adriamycin,NSC 123127,DOX,Hydroxydaunorubicin)HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage,mitophagy and apoptosis in tumor cells.Doxorubicin reduces basal phosphorylation of AMPK.Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.	price>
R-R-3428	Cinitapride CAS No.66564-14-5	Cinitapride/CAS No.66564-14-5 is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research.	price>
R-C-1729	Besifloxacin hydrochloride CAS: 405165-61-9	Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic.	price>
R-R-3429	EMDT oxalate CAS No.263744-72-5	EMDT oxalate/CAS No.263744-72-5 is a selective 5-HT6 agonist, and has antidepressant effects.	price>
R-C-1730	FGF-401 CAS: 1708971-55-4	Roblitinib(FGF401)is an FGFR4-selective inhibitor with an IC50 of 1.1nM.It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.	price>
R-R-3430	Lerisetron CAS No.143257-98-1	Lerisetron/CAS No.143257-98-1 is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats.	price>
R-C-1731	Vorapaxar (MK-5348) CAS: 618385-01-6	Vorapaxar(SCH 530348),an antiplatelet agent,is a selective,orally active,and competitive thrombin receptor protease-activated receptor(PAR-1)antagonist (Ki=8.1nM).Vorapaxar(SCH 530348)inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.	price>

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