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Catalog	name	Description	price
R-C-1591	ON123300 CAS:1357470-29-1	ON123300,a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4(IC50=3.9nM),Ark5(IC50=5nM),PDGFRβ(IC50=26 nM),FGFR1(IC50=26 nM),RET(IC50=9.2nM),and FYN(IC50=11nM).Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors.ON123300 inhibits CDK6 with an IC50 of 9.82 nM.	price>
R-R-3291	Rodatristat CAS No.1673568-73-4	Rodatristat (KAR5417)/CAS No.1673568-73-4 is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.	price>
R-C-1592	Napabucasin (BBI608) CAS:83280-65-3	Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells.	price>
R-R-3292	Rodatristat ethyl CAS No.1673571-51-1	Rodatristat ethyl (KAR5585)/CAS No.1673571-51-1 is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).	price>
R-C-1593	LMK-235 CAS:1418033-25-6	LMK-235 is a potent and selective HDAC4/5 inhibitor,inhibits HDAC5,HDAC4, HDAC6,HDAC1,HDAC2,HDAC11 and HDAC8,with IC50s of 4.22 nM,11.9nM,55.7nM,320 nM,881 nM,852 nM and 1278 nM,respectively,and is used in cancer research.	price>
R-R-3293	Risperidone-d4 CAS No.1020719-76-9	Risperidone-d4/CAS No.1020719-76-9 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.	price>
R-C-1594	GSK 429286A CAS:864082-47-3	GSK429286A is a cell-permeable,selective small molecule inhibitor of Rho-associated,coiled-coil containing protein kinase(ROCK).	price>
R-R-3294	Cariprazine-d6 CAS No.1308278-67-2	Cariprazine-d6/CAS No.1308278-67-2 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM).	price>
R-R-3295	Spiperone hydrochloride CAS No.2022-29-9	Spiperone hydrochloride (Spiroperidol hydrochloride)/CAS No.2022-29-9 is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.	price>
R-C-1596	Daprodustat(GSK1278863) CAS:960539-70-2	Daprodustat(GSK1278863)is an orally active hypoxia-inducible factor prolyl hydroxylase(HIF-PH)inhibitor being developed for the treatment of anemia associated with chronic kidney disease.	price>
R-R-3296	BIMU 8 CAS No.134296-40-5	BIMU 8/CAS No.134296-40-5 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.	price>
R-C-1597	CH5183284(Debio-1347) CAS:1265229-25-1	CH5183284(Debio-1347,FF284)is a selective and orally available FGFR inhibitor with IC50 of 9.3nM,7.6nM,22 nM,and 290nM for FGFR1,FGFR2,FGFR3,and FGFR4, respectively.	price>
R-R-3297	PF-04995274 CAS No.1331782-27-4	PF-04995274/CAS No.1331782-27-4 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S).	price>
R-C-1598	BMS582949(HCl) CAS:912806-16-7 (HCl)	BMS-582949(PS540446)is a potent and selective p38 mitogen-activated protein kinase(p38 MAPK)inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.	price>
R-R-3298	LP 12 hydrochloride hydrate	LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively).	price>
R-C-1599	ADX 47273 CAS:851881-60-2	ADX-47273 is a potent,selective and brain-penetrant mGluR5 positive allosteric modulator(PAM),with an EC50 of 0.17 μM for potentiation of glutamate(50nM) response.ADX-47273 has antipsychotic and procognitive activities.	price>
R-R-3299	Temanogrel CAS No.887936-68-7	Temanogrel/CAS No.887936-68-7 is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.	price>
R-C-1600	ozanimod CAS:1306760-87-1	Ozanimod(RPC-1063)is a potent and selective S1P1 and S1P5 receptor agonist with EC50s of 410 pM and 11 nM in [35S]-GTPγS binding,respectively.	price>
R-R-3300	Cariprazine-d8 CAS No.1308278-50-3	Cariprazine-d8/CAS No.1308278-50-3 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).	price>
R-C-1601	K-Ras-IN-1 CAS:84783-01-7	K-Ras-IN-1 is a K-Ras inhibitor.K-Ras-IN-1 binds to K-Ras(WT),K-Ras(G12D),K-Ras(G12V),and H-Ras.K-Ras-IN-1 has potential for the research of pancreatic, colon and lung carcinomas.	price>

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