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Catalog	name	Description	price
R-C-1606	Entacapone CAS：130929-57-6	Entacapone(OR-611)inhibits catechol-O-methyltransferase(COMT)with IC50 of 151 nM.Entacapone can be used for the research of Parkinson is disease.Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.	price>
R-R-3306	Eltoprazine hydrochloride CAS No.98206-09-8	Eltoprazine (DU 28853) hydrochloride/CAS No.98206-09-8 is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects.	price>
R-C-1607	FGFR4-IN-1 CAS：1708971-72-5	FGFR4-IN-1 is a potent and selective FGFR4 inhibitor.FGFR4 may be a novel therapeutic target for gastric cancer.	price>
R-R-3307	Eplivanserin hemifumarate CAS No.130580-02-8	Eplivanserin (SR-46349) hemifumarate/CAS No.130580-02-8 is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin hemifumarate displays >20-fold selectivity more selective for 5-HT2A than 5-HT2B and 5-HT2C.	price>
R-C-1608	DBPR-114 CAS：2443767-35-7	BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA,respectively,acts as a preclinical development candidate for anti-cancer therapy.	price>
R-R-3308	4F 4PP oxalate CAS No.144734-36-1	4F 4PP (oxalate)/CAS No.144734-36-1 is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM).	price>
R-C-1609	ACY738 CAS:1375465-91-0	ACY-738 is a potent,selective and orally-bioavailable HDAC6 inhibitor,with an IC50 of 1.7 nM;ACY-738 also inhibits HDAC1,HDAC2,and HDAC3,with IC50s of 94,128,and 218 nM.	price>
R-R-3309	PNU-142633 CAS No.187665-65-2	PNU-142633/CAS No.187665-65-2 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy.	price>
R-C-1610	Abivertinib maleate CAS:1557268-88-8	Abivertinib,also known as avitinib,AC0010 or AC0010MA,is an orally available, irreversible,epidermal growth factor receptor(EGFR)mutant-selective inhibitor, with potential antineoplastic activity.Upon oral administration,avitinib covalently binds to and inhibits the activity of mutant forms of EGFR,including the drug-resistant T790M EGFR mutant,which prevents signaling mediated by mutant forms of EGFR.This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells.EGFR,a receptor tyrosine kinase that is mutated in a variety of cancers,plays a key role in tumor cell proliferation and tumor vascularization.As this agent is selective towards mutant forms of EGFR,its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.	price>
R-R-3310	5-HT1A modulator 1 CAS No.142477-34-7	5-HT1A modulator 1/CAS No.142477-34-7 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.	price>
R-C-1611	SAR348830 CAS:1462949-64-9	SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).	price>
R-R-3311	E-3620 CAS No.151213-86-4	E-3620/CAS No.151213-86-4 is a potent 5-HT3 receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility.	price>
R-C-1612	CXD101 CAS： 934828-12-3	CXD101 is a potent,selective and orally active class I HDAC inhibitor with IC50s of 63 nM,570 nM and 550 nM for HDAC1,HDAC2 and HDAC3, respectively.CXD101 has no activity against HDAC class II.CXD101 has antitumor activity.	price>
R-R-3312	S-14506 hydrochloride CAS No.286369-38-8	S-14506 hydrochloride/CAS No.286369-38-8 is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.	price>
R-C-1613	Pluripotin (SC1) CAS：839707-37-8	Pluripotin(SC1)is a dual inhibitor of extracellular signal-regulated kinase 1(ERK1,MAPK3)and RasGAP.Maintains embryonic stem cell(ESC)self-renewal.Pluripotin also inhibits RSK1,RSK2,RSK3 and RSK4 with IC50 of 0.5 µM,2.5 µM,3.3µM and 10.0µM,respectively.	price>
R-R-3313	Amperozide CAS No.75558-90-6	Amperozide/CAS No.75558-90-6 is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors.	price>
R-C-1614	BMS309403 CAS：300657-03-8	BMS-309403 is a potent,orally active and selective adipocyte fatty acid binding protein(also known as FABP4,aP2)inhibitor with Kis of <2,250,and 350 nM for FABP4,FABP3,and FABP5,respectively.BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids.BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.	price>
R-R-3314	BMY 14802 CAS No.105565-56-8	BMY 14802/CAS No.105565-56-8 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors.	price>
R-C-1615	SIS3 HCL CAS：521984-48-5	SIS3 is a novel specific inhibitor of Smad3.It has effect on transforming growth factor-beta1-induced extracellular matrix expression.	price>
R-R-3315	LY 165163 CAS No.1814-64-8	LY 165163/CAS No.1814-64-8 is a potent 5-HT presynaptic receptor agonist. LY 165163 significantly decreases 5-HTP accumulation and increases DOPA accumulation in the cortex and striatum.	price>

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