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Catalog	name	Description	price
R-R-3285	Renzapride CAS No.112727-80-7	Renzapride (BRL 24924)/CAS No.112727-80-7, a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.	price>
R-C-1586	TGX-221 CAS:663619-89-4	TGX-221 is a potent,selective,and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit,used for cancer treatment.	price>
R-R-3286	Dolasetron Mesylate hydrate CAS No.878143-33-0	Dolasetron Mesylate hydrate (MDL-73147EF hydrate)/CAS No.878143-33-0 is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.	price>
R-C-1587	T-5224 CAS:530141-72-1	T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects.T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3,Mmp-13 and Adamts-5 transcription.	price>
R-R-3287	Ampreloxetine TFA	Ampreloxetine (TD-9855) TFA is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine TFA has the potential for the research of neurogenic orthostatic hypotension.	price>
R-C-1588	Scriptaid CAS:287383-59-9	Scriptaid is a potent histone deacetylase(HDAC)inhibitor,used in cancer research.Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus(EBV)-associated lymphomas treatment.	price>
R-R-3288	BRL-15572 dihydrochloride CAS No.193611-72-2	BRL-15572 dihydrochloride/CAS No.193611-72-2 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.	price>
R-C-1589	SB 366791 CAS:472981-92-3	SB-366791 is a potent,competitive and selective vanilloid receptor(VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM target:VR1/TRPV1 IC 50:5.7±1.2 nM[1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08.	price>
R-R-3289	Quetiapine-d4 fumarate CAS No.1287376-15-1	Quetiapine-d4 (fumarate)/CAS No.1287376-15-1 is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.	price>
R-C-1590	Apabetalone (RVX-208) CAS:1044870-39-4	Apabetalone(RVX-208)is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.The IC50s are 87 μM and 0.51 μM for BD1 and BD2,respectively.	price>
R-R-3290	Buspirone CAS No.36505-84-7	Buspirone/CAS No.36505-84-7 is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research.	price>
R-C-1591	ON123300 CAS:1357470-29-1	ON123300,a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4(IC50=3.9nM),Ark5(IC50=5nM),PDGFRβ(IC50=26 nM),FGFR1(IC50=26 nM),RET(IC50=9.2nM),and FYN(IC50=11nM).Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors.ON123300 inhibits CDK6 with an IC50 of 9.82 nM.	price>
R-R-3291	Rodatristat CAS No.1673568-73-4	Rodatristat (KAR5417)/CAS No.1673568-73-4 is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.	price>
R-C-1592	Napabucasin (BBI608) CAS:83280-65-3	Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells.	price>
R-R-3292	Rodatristat ethyl CAS No.1673571-51-1	Rodatristat ethyl (KAR5585)/CAS No.1673571-51-1 is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).	price>
R-C-1593	LMK-235 CAS:1418033-25-6	LMK-235 is a potent and selective HDAC4/5 inhibitor,inhibits HDAC5,HDAC4, HDAC6,HDAC1,HDAC2,HDAC11 and HDAC8,with IC50s of 4.22 nM,11.9nM,55.7nM,320 nM,881 nM,852 nM and 1278 nM,respectively,and is used in cancer research.	price>
R-R-3293	Risperidone-d4 CAS No.1020719-76-9	Risperidone-d4/CAS No.1020719-76-9 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.	price>
R-C-1594	GSK 429286A CAS:864082-47-3	GSK429286A is a cell-permeable,selective small molecule inhibitor of Rho-associated,coiled-coil containing protein kinase(ROCK).	price>
R-R-3294	Cariprazine-d6 CAS No.1308278-67-2	Cariprazine-d6/CAS No.1308278-67-2 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM).	price>
R-R-3295	Spiperone hydrochloride CAS No.2022-29-9	Spiperone hydrochloride (Spiroperidol hydrochloride)/CAS No.2022-29-9 is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.	price>

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