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Catalog	name	Description	price
R-R-3265	Strictosidinic acid CAS No.150148-81-5	Strictosidinic acid/CAS No.150148-81-5, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.	price>
R-C-1566	Selonsertib (GS-4997) CAS：1448428-04-3	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1(ASK1),with potential anti-inflammatory,antineoplastic and anti-fibrotic activities.	price>
R-R-3266	Felcisetrag CAS No.916075-84-8	Felcisetrag (TD-8954)/CAS No.916075-84-8 is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.	price>
R-C-1567	Pamapimod CAS：449811-01-2	Pamapimod(Ro4402257)is a potent,selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β,respectively.Pamapimod has no activity against p38δ or p38γ isoforms.Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.	price>
R-R-3267	Pirenperone CAS No.75444-65-4	Pirenperone (R 47465)/CAS No.75444-65-4 is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity.	price>
R-C-1568	Navitoclax (ABT-263) CAS：923564-51-6	Navitoclax(ABT-263)is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins,such as Bcl-xL,Bcl-2 and Bcl-w,with a Ki of less than 1nM.	price>
R-R-3268	GR 55562 dihydrochloride CAS No.159533-25-2	GR 55562 (dihydrochloride)/CAS No.159533-25-2 is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease.	price>
R-C-1569	Tavaborole (AN-2690) CAS：174671-46-6	AN-2690,an antifungal agent with activity against Trichophyton species,in a topical solution formulation,for the potential treatment of onychomycosis.	price>
R-R-3269	Perospirone hydrochloride CAS No.129273-38-7	Perospirone hydrochloride (SM-9018)/CAS No.129273-38-7 is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-C-1570	ETP46464 CAS：1345675-02-6	ETP46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated(ATM)-and Rad3-related(ATR).	price>
R-R-3270	Urapidil CAS No.34661-75-1	Urapidil/CAS No.34661-75-1 is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.	price>
R-C-1571	Fenebrutinib (GDC-0853) CAS：1434048-34-6	Fenebrutinib(GDC-0853)is a potent,selective, orally available,and noncovalent bruton is tyrosine kinase(Btk)inhibitor with Kis of 0.91 nM,1.6,1.3,12.6,and 3.4 nM for WT Btk,and the C481S,C481R,T474I,T474M mutants.Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.	price>
R-R-3271	RS 67333 hydrochloride CAS No.168986-60-5	RS 67333 hydrochloride/CAS No.168986-60-5 is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors.	price>
R-C-1572	A66 CAS：1166227-08-2	A66 is a potent and highly selective p110α inhibitor with IC50 of 32 nM in a cell-free assay,>100 fold selectivity for p110α over other class-I PI3K isoforms.A66 blocks phosphoinositide 3-kinase signalling and tumour growth in certain cell types.	price>
R-R-3272	Naronapride CAS No.860174-12-5	Naronapride (ATI-7505)/CAS No.860174-12-5 is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research.	price>
R-C-1573	ML348 CAS:899713-86-1	ML348 is a selective and reversible lysophospholipase 1(LYPLA1)inhibitor(IC50 =210nM),Exhibits 14-fold selectivity for LYPLA1 over LYPLA2,Also selective over a panel of ~30 other serine hydrolases.	price>
R-R-3273	Amitriptyline-d3 hydrochloride CAS No.342611-00-1	Amitriptyline-d3 hydrochloride/CAS No.342611-00-1 is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-C-1574	mpi-0479605 CAS：1246529-32-7	MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1.Cells treated with MPI-0479605 undergo aberrant mitosis,resulting in aneuploidy and formation of micronuclei.In cells with wild-type p53,this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway.In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis.Subsequently,cells undergo mitotic catastrophe and/or an apoptotic response.In xenograft models, MPI-0479605 inhibits tumor growth,suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.	price>
R-R-3274	l-Pindolol CAS No.26328-11-0	l-Pindolol ((-)-pindolol)/CAS No.26328-11-0 is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease.	price>
R-C-1575	QVD-oph CAS：1135695-98-5	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties;inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1,3,8,9,10,and 12.Q-VD-OPh can inhibits HIV infection.Q-VD-OPh is able to cross the blood-brain barrier.	price>

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