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Catalog	name	Description	price
R-R-3225	Frovatriptan succinate hydrate CAS No.158930-17-7	Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate)/CAS No.158930-17-7 is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research.	price>
R-C-1526	ABT-639 CAS:1235560-28-7	ABT-639 is a potent and selective T-type calcium channel blocker.ABT-639 effectively reduces nociceptive and neuropathic pain in rats.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.ABT-639 was significantly less active at other Ca²⁺channels(e.g.Ca(v)1.2 and Ca(v)2.2) (IC50>30μM).ABT-639 has high oral bioavailability(%F=73),low protein binding(88.9%)and a low brain:plasma ratio(0.05:1)in rodents.	price>
R-R-3226	Fananserin CAS No.127625-29-0	Fananserin (RP 62203)/CAS No.127625-29-0 is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.	price>
R-C-1527	SH-4-54 CAS:1456632-40-8	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5,respectively.SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs)and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.Moreover,in vivo,SH-4-54 exhibited blood-brain barrier permeability,potently controlled glioma tumor growth,and inhibited pSTAT3 in vivo.	price>
R-R-3227	RS-102221 hydrochloride CAS No.187397-18-8	RS-102221 hydrochloride/CAS No.187397-18-8 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.	price>
R-C-1528	CHIR-090 CAS: 728865-23-4	CHIR-090 is a potent,slow,tight-binding inhibitor of the LpxC deacetylase.It binds to E.coli LpxC with a Ki of 4.0nM.	price>
R-R-3228	Bemesetron CAS No.40796-97-2	Bemesetron (MDL 72222)/CAS No.40796-97-2 is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.	price>
R-C-1529	MS023 CAS:1831110-54-3	MS023 is a potent,selective,and cell-active inhibitor of human type I protein arginine methyltransferases(PRMTs)inhibitor,with IC50s of 30,119,83,4 and 5nM for PRMT1,PRMT3,PRMT4,PRMT6,and PRMT8,respectively.	price>
R-R-3229	Altanserin CAS No.76330-71-7	Altanserin/CAS No.76330-71-7 can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors.	price>
R-C-1530	GSK591（EPZ-015866） CAS:1616391-87-7	GSK591(EPZ015866)is a potent and selective inhibitor of protein methyltransferase 5(PRMT5)with an IC50 of 4 nM.	price>
R-R-3230	Agomelatine-d6 CAS No.1079389-42-6	Agomelatine-d6/CAS No.1079389-42-6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors .	price>
R-C-1531	Binimetinib (MEK-162, ARRY-162, ARRY-438162)	Binimetinib(MEK162)is an oral and selective MEK1/2 inhibitor.Binimetinib (MEK162)inhibits MEK with an IC50 of 12 nM.	price>
R-R-3231	SB-203186 hydrochloride CAS No.207572-69-8	SB-203186 hydrochloride/CAS No.207572-69-8 is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively.	price>
R-C-1532	Galeterone CAS:851983-85-2	Galeterone(TOK-001)is a selective CYP17 inhibitor and androgen receptor (AR)antagonist with IC50 of 300 nM and 384 nM,respectively,and is a potent inhibitor of human prostate tumor growth.	price>
R-R-3232	VUF10166 CAS No.155584-74-0	VUF10166/CAS No.155584-74-0 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM.	price>
R-C-1533	GSK163090 CAS:844903-58-8	GSK163090 is a potent,selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7,respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter(SerT)with a pKi value of 6.1.GSK163090 has antidepressant and anxiolytic activities.	price>
R-R-3233	SB-399885 hydrochloride CAS No.402713-81-9	SB-399885 hydrochloride/CAS No.402713-81-9 is a 5-HT6 receptor antagonist.	price>
R-C-1534	AMG319 CAS : 1608125-21-8	AMG-319(ACP319)is a highly selective,potent,and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases(PI3K)with potential immunomodulating and antineoplastic activities.PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate(PIP3),thus decreasing proliferation and inducing cell death.	price>
R-R-3234	BMY-14802 hydrochloride CAS No.105565-55-7	BMY-14802 hydrochloride (BMY-14802-1)/CAS No.105565-55-7 is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.	price>
R-C-1535	Vipadenant(BIIB 014) CAS:442908-10-3	Vipadenant,also known as BIIB014,CEB-4520,is a potent,selective and orally available adenosine A2A receptor antagonist under development for Parkinson is disease.Vipadenant demonstrates strong oral activity in commonly used models of Parkinson is disease.	price>

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