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Catalog	name	Description	price
R-C-1475	PGA-PEG-malemide	Polyglutamic acid（γ-PGA,also known as natto gum and polyglutamic acid,is a kind of water-soluble,biodegradable,non-toxic biopolymer produced by microbial fermentation.Polyethylene glycol(PEG)is a kind of high molecular polymer,the chemical formula is ho(CH2CH2O)NH,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.	price>
R-R-3175	Phenylbiguanide CAS No.102-02-3	Phenylbiguanide/CAS No.102-02-3 is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.	price>
R-C-1476	MK-3697 CAS:1224846-01-8	MK-3697 is a highly potent,orally bioavailable selective orexin 2 receptor antagonists.MK-3697 is also the third insomnia drug,currently being developed by Merck.MK-3697 has Ki=0.95nM.Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia.In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species.	price>
R-R-3176	Zacopride hydrochloride CAS No.101303-98-4	Zacopride hydrochloride/CAS No.101303-98-4 is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects.	price>
R-C-1477	bay1217389 CAS:1554458-53-5	BAY 1217389 is an orally bioavailable,selective inhibitor of the serine/threonine kinase monopolar spindle 1(Mps1)with IC50 values below 10 nmol/L while showing an excellent selectivity profile.	price>
R-R-3177	Flibanserin CAS No.167933-07-5	Flibanserin (BIMT-17; BIMT-17BS)/CAS No.167933-07-5 is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.	price>
R-C-1478	PF-2545920 CAS:1292799-56-4	Mardepodect(PF-2545920)is a potent,orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM,with>1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier.	price>
R-R-3178	Iloperidone CAS No.133454-47-4	Iloperidone (HP 873)/CAS No.133454-47-4 is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms.	price>
R-C-1479	SEA0400 CAS:223104-29-8	SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger(NCX)that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes,and microglia with IC50 of 33 nM,5.0nM and 8.3 nM,respectively.SEA0400 prevents sodium nitroprusside(SNP)from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species(ROS)in an extracellular Ca(2+)-dependent manner.	price>
R-R-3179	Naratriptan hydrochloride CAS No.143388-64-1	Naratriptan hydrochloride/CAS No.143388-64-1 is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.	price>
R-C-1480	MBX-2982 CAS:1037792-44-1	MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119(GPR119),a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion.	price>
R-R-3180	Quipazine CAS No.4774-24-7	Quipazine/CAS No.4774-24-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research.	price>
R-C-1481	GSK2330672 CAS:1345982-69-5	Linerixibat(GSK2330672)is a highly potent,nonabsorbable and orally active apical sodium-dependent bile acid transporter(ASBT)inhibitor with an IC50 of 42 nM human ASBT.Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment.	price>
R-R-3181	NAN-190 hydrobromide CAS No.115338-32-4	NAN-190 hydrobromide/CAS No.115338-32-4 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.	price>
R-C-1482	CNX-2006 CAS：1375465-09-0	CNX-2006 is a potent,mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations,as well as in cells harbouring the T790M mutation.CNX-2006 is the prototype for CO-1686,which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.	price>
R-R-3182	Mirtazapine-d3 CAS No.1216678-68-0	Mirtazapine-d3/CAS No.1216678-68-0 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors.	price>
R-C-1483	Verteporfin (CL 318952) CAS：129497-78-5	Verteporfin(CL 318952,Visudyne)is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.It is also a potent second-generation photosensitizing agent derived from porphyrin.Verteporfin is an autophagy inhibitor.Verteporfin inhibits cell proliferation and induces apoptosis.	price>
R-R-3183	WAY-181187 CAS No.554403-49-5	WAY-181187 (SAX-187)/CAS No.554403-49-5 is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.	price>
R-C-1484	Cyclopamine CAS：4449-51-8	Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids.It is a teratogen isolated from the corn lily (Veratrum californicum)that causes usually fatal birth defects.It can prevent the fetal brain from dividing into two lobes(holoprosencephaly)and cause the development of a single eye(cyclopia).	price>
R-R-3184	SB 243213 CAS No.200940-22-3	SB 243213/CAS No.200940-22-3 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.	price>

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