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Catalog	name	Description	price
R-R-3134	Gamma-Mangostin CAS No.31271-07-5	Gamma-Mangostin/CAS No.31271-07-5 is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) .	price>
R-C-1435	LLY-507 CAS：1793053-37-8	LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2,LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50<15 nM.LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.	price>
R-R-3135	Roluperidone CAS No.359625-79-9	Roluperidone (CYR-101)/CAS No.359625-79-9 is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).	price>
R-C-1436	HLCL-61 HCL CAS：1158279-20-9	HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML(acute myeloid leukemia)cells.As a result,significant antileukemic activity was achieved.The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it.In AML cells,PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	price>
R-R-3136	Syk Inhibitor II CAS No.726695-51-8	Syk Inhibitor II/CAS No.726695-51-8 is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect.	price>
R-C-1437	AG18 CAS：118409-57-7	AG-18（RG-50810;RG-50858;TX 825;Tyrphostin A23;Tyrphostin AG-18）AG-18 is an inhibitor of epidermal growth factor(EGF)receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431.AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.	price>
R-R-3137	R 59-022 CAS No.93076-89-2	R 59-022 (DKGI-I)/CAS No.93076-89-2 is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.	price>
R-C-1438	CYM5442 CAS：1094042-01-9	CYM5442 is a potent,highly-selective and orally active sphingosine 1-phosphate (S1P1)receptor agonist with an EC50 of 1.35 nM.CYM5442 is inactive against S1P2,S1P3,S1P4,and S1P5.CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation.CYM5442 exerts retinal neuroprotection.CYM5442 can easily penetrate the central nervous system(CNS).	price>
R-R-3138	Paliperidone palmitate CAS No.199739-10-1	Paliperidone palmitate (9-Hydroxyrisperidone palmitate)/CAS No.199739-10-1, an atypical long-acting antipsychotic agent, is an ester proagent of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.	price>
R-C-1439	u-104 CAS：178606-66-1	U-104(SLC-0111)is a potent carbonic anhydrase(CA)inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM,respectively.U-104 shows a significant delay in tumor growth in mice model.	price>
R-R-3139	Prucalopride succinate CAS No.179474-85-2	Prucalopride succinate/CAS No.179474-85-2 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>
R-C-1440	OAC1 CAS：300586-90-7	OAC1 is an Oct-4 activator,octamer-binding transcription factor 4(Oct4)-activating compound,that enhances the iPSC reprogramming efficiency and accelerated the reprogramming process by 20-fold.OAC-1 also upregulates mRNA expression of Oct-4,Sox-2 and Nanog,as well as Tet1.	price>
R-R-3140	Rotigotine CAS No.99755-59-6	Rotigotine/CAS No.99755-59-6 is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor.	price>
R-C-1441	OAC2 CAS：6019-39-2	OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.Octamer-binding transcription factor 4(Oct4)is a transcription factor which,with Sox2,Klf4,and c-Myc,is involved in the reprogramming of somatic cells to produce pluripotent stem cells.	price>
R-R-3141	Granisetron Hydrochloride CAS No.107007-99-8	Granisetron (Hydrochloride) (BRL 43694A)/CAS No.107007-99-8 is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.	price>
R-R-3142	Palonosetron hydrochloride CAS No.135729-62-3	Palonosetron hydrochloride/CAS No.135729-62-3 is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).	price>
R-C-1443	Apilimod (STA-5326) CAS：541550-19-0	Apilimod(STA-5326)is a potent and orally-available inhibitor of the cytokines interleukin-12(IL-12)and interleukin-23(IL-23)with the potential to treat certain autoimmune and inflammatory diseases.Apilimod(STA-5326)inhibits IL-12 with IC50 of 1 nM,1 nM and 2 nM,in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs,respectively.Apilimod (STA-5326)is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.	price>
R-R-3143	Sarpogrelate hydrochloride CAS No.135159-51-2	Sarpogrelate hydrochloride (MCI-9042)/CAS No.135159-51-2 is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis.	price>
R-C-1444	Santacruzamate A (CAY10683) CAS:1477949-42-0	Santacruzamate A(CAY10683)is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2,>3600-fold selectivity over other HDACs.	price>
R-R-3144	Sarizotan CAS No.351862-32-3	Sarizotan (EMD 128130)/CAS No.351862-32-3 is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.	price>

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