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Catalog	name	Description	price
R-C-1290	Filgotinib (GLPG0634) CAS：1206161-97-8	Filgotinib,also known as GLPG0634,is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis(RA)and Crohn is disease.It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1-over JAK2-dependent signaling.GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.	price>
R-R-2990	BQU57 CAS No.1637739-82-2	BQU57/CAS No.1637739-82-2 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.	price>
R-C-1291	Fimepinostat (CUDC-907) CAS：1339928-25-4	Fimepinostat(CUDC-907)potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10,respectively.	price>
R-R-2991	CCG-203971 CAS No.1443437-74-8	CCG-203971/CAS No.1443437-74-8 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent.	price>
R-C-1292	Vacquinol-1 CAS# 5428-80-8	Vacquinol-1,also known as NSC 13316,is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration.In glioblastoma cells,Vacquinol-1 targets macropinocytosis,a cellular process that will not lead to cell death in normal cells.	price>
R-R-2992	Rasarfin CAS No.674359-73-0	Rasarfin/CAS No.674359-73-0 is a dual Ras and ARF6 inhibitor.	price>
R-C-1293	NS 11021 CAS:956014-19-0	NS-11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa,KCa1.1).BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.NS11021 enhances erectile responses in rats.	price>
R-R-2993	CE3F4 CAS No.143703-25-7	CE3F4/CAS No.143703-25-7 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.	price>
R-C-1294	KO143 CAS:461054-93-3	Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP)inhibitor.Ko 143 displays>200-fold selectivity over P-gp and MRP-1 transporters.	price>
R-R-2994	RMC-0331 CAS No.2488788-52-7	RMC-0331 (RM-023)/CAS No.2488788-52-7 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.	price>
R-C-1295	BAZ2-ICR CAS:1665195-94-7	BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. BAZ2-ICR has IC50(BAZ2A)=130 nM;IC50(BAZ2B)=180 nM;logD=1.05;solubility 25 mM (D2O)and F=70%.	price>
R-R-2995	RAS inhibitor Abd-7 CAS No.2351843-48-4	RAS inhibitor Abd-7/CAS No.2351843-48-4, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.	price>
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>
R-C-1297	Ceralasertib (AZD6738) CAS:1352226-88-0	Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.	price>
R-R-2997	8-CPT-2Me-cAMP sodium CAS No.634207-53-7	8-CPT-2Me-cAMP sodium/CAS No.634207-53-7 is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.	price>
R-C-1298	SBI0206965 CAS:1884220-36-3	SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor.Many tumors become addicted to autophagy for survival,suggesting inhibition of autophagy as a potential broadly applicable cancer therapy.SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells,regulating autophagy and cell survival.	price>
R-R-2998	MLS-573151 CAS No.10179-57-4	MLS-573151 (MLS000573151)/CAS No.10179-57-4 is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42.	price>
R-C-1299	SC79 CAS:305834-79-1	SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation,in the cytosol,by upstream kinases.SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head.SC-79 injections inhibited alcohol-induced osteonecrosis.Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.	price>
R-R-2999	AZA1 CAS No.1071098-42-4	AZA1/CAS No.1071098-42-4 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.	price>
R-C-1300	TAS-301 CAS:193620-69-8	TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery.TAS-103 inhibits smooth muscle cell migration and proliferation.TAS-103 inhibits intimal thickening after balloon injury to rat carotid arteries.TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.TAS-103 inhibits calcium-dependent signal transduction and cytoskeletal reorganization.	price>

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