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Catalog	name	Description	price
R-C-1382	Volitinib CAS:1313725-88-0	Savolitinib,also known as Volitinib,AZD6094 or HMPL-504,is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner,and disrupts c-Met signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress the c-Met protein.	price>
R-R-3082	Vortioxetine CAS No.508233-74-7	Vortioxetine/CAS No.508233-74-7 is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1383	FMK CAS:821794-92-7	FMK is potent,highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2;Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386.Fmk induces significant apoptosis in human FGFR3-expressing,t(4;14)-positive multiple myeloma cells.	price>
R-R-3083	Ondansetron CAS No.99614-02-5	Ondansetron (GR 38032; SN 307)/CAS No.99614-02-5 is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity.	price>
R-C-1384	Voreloxin CAS:175414-77-4	Voreloxin,also known as SNS-595 or Vosaroxin,is a s mall molecule and a naphthyridine analogue with antineoplastic activity.Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result,inhibition of DNA replication,RNA and protein synthesis occurs,followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis.This agent shows a favorable toxicity profile in several aspects:it does not generate reactive oxygen species,as do anthracyclines,reducing the risk of cardiotoxicity.	price>
R-R-3084	Brexpiprazole CAS No.913611-97-9	Brexpiprazole (OPC-34712)/CAS No.913611-97-9, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).	price>
R-C-1385	Capadenoson,BAY 68-4986 CAS:544417-40-5	Capadenoson is a selective agonist of adenosine-A1 receptor.	price>
R-R-3085	SEP-363856 hydrochloride CAS No.1310422-41-3	SEP-363856 hydrochloride (SEP-856 hydrochloride)/CAS No.1310422-41-3, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride (SEP-856 hydrochloride) has the potential for the study of schizophrenia.	price>
R-C-1386	PF-3758309 CAS: 898044-15-0	PF-3758309,also known as PF-03758309,is a PAK4 inhibitor,is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4(PAK4)with potential antineoplastic activity.PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth.PAK4,a serine/threonine kinase belonging to the p21-activated kinase(PAK)family,is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility,proliferation,and survival.	price>
R-R-3086	Volinanserin CAS No.139290-65-6	Volinanserin/CAS No.139290-65-6 is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.	price>
R-C-1387	Preladenant CAS:377727-87-2	Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.	price>
R-R-3087	Ritanserin CAS No.87051-43-2	Ritanserin (R 55667)/CAS No.87051-43-2 is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.	price>
R-C-1388	CWHM12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-R-3088	Paliperidone CAS No.144598-75-4	Paliperidone (9-Hydroxyrisperidone)/CAS No.144598-75-4, the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.	price>
R-C-1389	NMS-873 CAS:1418013-75-8	NMS-873 is a potent, allosteric and specific VCP inhibitor(also known as p97 inhibitor)with IC50 of 30 nM.NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death.The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.	price>
R-R-3089	Vortioxetine hydrobromide CAS No.960203-27-4	Vortioxetine hydrobromide/CAS No.960203-27-4 is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1390	Nutlin-3 CAS：890090-75-2	Nutlin-3,also known as(±)-Nutlin-3 and N-6287,is a p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment.Nutlin-3 specifically targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells.Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.	price>
R-R-3090	WAY-100635 maleate CAS No.1092679-51-0	WAY-100635 maleate/CAS No.1092679-51-0 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist.	price>
R-C-1391	Deltarasin CAS：1440898-61-2	Deltazinone is highly potent and selective PDEδ inhibitor.Deltazinone exhibits less unspecific cytotoxicity than the previously reported Deltarasin and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines.	price>
R-R-3091	8-OH-DPAT CAS No.78950-78-4	8-OH-DPAT /CAS No.78950-78-4 is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).	price>

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