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Catalog	name	Description	price
R-C-1276	CHS 828 CAS：200484-11-3	CHS-828(GMX1778)is a competitive inhibitor of nicotinamide phosphoribosyltransferase(NAMPT),with an IC50 less than 25 nM.CHS-828 (GMX1778)exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.	price>
R-R-2976	CASIN CAS No.425399-05-9	CASIN/CAS No.425399-05-9 is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.	price>
R-C-1277	CK 1827452 CAS：873697-71-3	Omecamtiv mecarbil, also known as CK-1827452,is a cardiac specific myosin activator.It is clinically tested for its role in the treatment of left ventricular systolic heart failure.Omecamtiv Mecarbil specifically targets and activates myocardial ATPase and improves energy utilization.Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume,without consuming more ATP energy,oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.	price>
R-R-2977	Salirasib CAS No.162520-00-5	Salirasib/CAS No.162520-00-5 is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.	price>
R-C-1278	LP-533401 CAS：945976-43-2	LP533401 is an inhibitor of tryptophan hydroxylase 1,which regulates serotonin production in the gut.LP533401 has an anabolic effect in bone.Inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis.	price>
R-R-2978	ML-098 CAS No.878978-76-8	ML-098 (CID-7345532)/CAS No.878978-76-8 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.	price>
R-C-1279	Vesnarinone CAS:81840-15-5	Vesnarinone is a cardiotonic agent,mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest,dose-dependent,positive inotropic activity,but minimal negative chronotropic activity.Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.	price>
R-R-2979	RAS-IN-2 CAS No.2765081-21-6	RAS-IN-2 (Compound A122)/CAS No.2765081-21-6 is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.	price>
R-C-1280	AZ-33 CAS：1370290-34-8	AZ-33(LDHA Inhibitor 33)is a potent inhibitor of lactate dehydrogenase A (LDHA)with IC50 of 0.5 μM.LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	price>
R-R-2980	MRTX-1257 CAS No.2206736-04-9	MRTX-1257/CAS No.2206736-04-9 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.	price>
R-C-1281	(Linsitinib)OSI-906 CAS：867160-71-2	Linsitinib(OSI-906)is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays;modestly potent to InsR with IC50 of 75 nM,and no activity towards Abl,ALK,BTK,EGFR,FGFR1/2,PKA etc.	price>
R-R-2981	FTI-277 hydrochloride CAS No.180977-34-8	FTI-277 hydrochloride/CAS No.180977-34-8 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.	price>
R-C-1282	AZD3759 CAS:1626387-80-1	AZD3759 is a potent,oral active,CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM,0.2nM,and 0.2nM for EGFR(WT),EGFR(L858R),and EGFR(exon 19Del),respectively.	price>
R-R-2982	Sotorasib racemate CAS No.2252403-56-6	Sotorasib racemate (Compound A)/CAS No.2252403-56-6 is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.	price>
R-C-1283	IKK16 CAS:873225-46-8	IKK-16(IKK Inhibitor VII)is a selective IκB kinase(IKK)inhibitor for IKK-2,IKK complex and IKK-1 with IC50 of 40 nM,70 nM and 200 nM in cell-free assays, respectively.IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.	price>
R-R-2983	Pan-RAS-IN-1 CAS No.1835283-94-7	Pan-RAS-IN-1/CAS No.1835283-94-7 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.	price>
R-C-1284	Andarine CAS：401900-40-1	Andarine(GTx-007,S-4)is a selective non-steroidal androgen receptor(AR)agonist with Ki of 4 nM,tissue-selective for anabolic organs.	price>
R-R-2984	BDP9066 CAS No.2226507-04-4	BDP9066/CAS No.2226507-04-4 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.	price>
R-C-1285	Testolone (RAD140) CAS：1182367-47-0	Testolone(RAD140)is a potent,orally bioavailable,nonsteroidal selective androgen receptor modulator with Ki value of 7 nM as well as good selectivity over other steroid hormone nuclear receptors.	price>
R-R-2985	CCG-222740 CAS No.1922098-69-8	CCG-222740/CAS No.1922098-69-8 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.	price>

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