Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-1342	Epacadostat (INCB024360) CAS：1204669-58-8	Epacadostat,also known as INCB024360 or INCB24360,is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase(IDO1)with potential immunomodulating and antineoplastic activities.INCB024360 targets and binds to IDO1,an enzyme responsible for the oxidation of tryptophan into kynurenine.By inhibiting IDO1 and decreasing kynurenine in tumor cells,INCB024360 increases and restores the proliferation and activation of various immune cells,including dendritic cells(DCs),NK cells,and T-lymphocytes,as well as interferon(IFN)production,and a reduction in tumor-associated regulatory T cells (Tregs).	price>
R-R-3042	SOS1 activator 1 CAS No.2245237-53-8	SOS1 activator 1 (Compound 64)/CAS No.2245237-53-8 is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS.	price>
R-C-1343	GLYX13 CAS：117928-94-6	Rapastinel,also known as GLYX-13 and BV-102,It is a centrally active, intravenously administered(non-orally active)amidated tetrapeptide(Thr-Pro-Pro-Thr-NH2)that acts as a selective,weak partial agonist(mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax≈25%).	price>
R-R-3043	Oncrasin-1 CAS No.75629-57-1	Oncrasin-1/CAS No.75629-57-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.	price>
R-C-1344	Ezetimibe (SCH-58235） CAS：163222-33-1	Ezetimibe,also known as SCH 58235,is a drug that lowers plasma cholesterol levels.It acts by decreasing cholesterol absorption in the small intestine.It may be used alone when other cholesterol-lowering medications are not tolerated, or together with statins(ezetimibe/simvastatin)when statins alone do not control cholesterol.	price>
R-R-3044	PROTAC SOS1 degrader-1 TFA	PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity.	price>
R-C-1345	Eliprodil (SL-820715） CAS：119431-25-3	Eliprodil,aslo known as SL-82,0715;is a NMDA antagonist.NMDA receptors are a key component in mediating glutamate-induced excitotoxicity,and it is believed that NMDA antagonists would be neuroprotective after a stroke or other traumatic brain injury.Eliprodil protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage.Eliprodil stimulates CNS myelination,may be a new prospect for multiple sclerosis.	price>
R-R-3045	AZD4747 CAS No.2489226-14-2	AZD4747/CAS No.2489226-14-2 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.	price>
R-C-1346	4E1Rcat CAS：328998-25-0	4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.1 It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.1 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.	price>
R-R-3046	K-Ras G12C-IN-3 CAS No.1629268-19-4	K-Ras G12C-IN-3/CAS No.1629268-19-4 is a novel and irreversible inhibitor of mutant K-ras G12C.	price>
R-C-1347	R-112 CAS： 575474-82-7	R112 is a Syk inhibitor.R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells(tryptase release,effective concentration for 50% inhibition[EC(50)]=353 nmol/L)or basophils(histamine release,EC(50)=280 nmol/L),and by allergen(dust mite)in basophils(histamine release,EC(50)=490 nmol/L).	price>
R-R-3047	PROTAC KRAS G12C degrader-2 CAS No.2378257-72-6	PROTAC KRAS G12C degrader-2 (compound 432)/CAS No.2378257-72-6 is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.	price>
R-C-1348	WAY181187.HCl CAS：554403-08-6	WAY-181187 is a potent and selective 5-HT6 receptor agonist.WAY-181187 possesses high affinity binding(2.2 and 4.8 nM,respectively)at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187:EC50=6.6 nM,Emax=93%).	price>
R-R-3048	Spiclomazine CAS No.24527-27-3	Spiclomazine (Clospirazine)/CAS No.24527-27-3 is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.	price>
R-C-1349	fluoroclebopride CAS No. 154540-49-5	Fluoroclebopride is a benzamide analog that is used in positron emission tomography(PET)applications.It binds reversibly to dopamine receptors(Kis= 0.95,5.7,5.46,and 144 nM for D2-like,D2(long),D3,and D4 receptors,respectively, in radioligand binding assays).It is selective for these receptors over D1, serotonin 5-HT2,and α2-adrenergic receptors(Kis=>10,000,283,and 1,300 nM, respectively).	price>
R-R-3049	GDC-6036-NH CAS No.2417918-80-8	GDC-6036-NH/CAS No.2417918-80-8 is from patent WO2020097537A2, and a precursor of compound 17 a/b. Compound 17 a/b is a RAS inhibitor and can be used in cancer research.	price>
R-C-1350	BIBS39 CAS:133085-33-3	BIBS 39 is a new nonpeptide angiotensin II(AII)receptor antagonist.Target: Angiotensin Receptorin vitro: BIBS 39 displaces[125I]AII from its specific binding sites with a Ki value of 29±7 nM for the AII subtype 1(AT1)receptor and a Ki value of 480±110 nM for the AII subtype 2(AT2)receptor.BIBS 222 shows a Ki value of 20±7 nM for the AT1 subtype and a Ki value of 730±170 nM for the AT2 subtype.BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times.	price>
R-R-3050	K-Ras G12C-IN-1 CAS No.1629265-17-3	K-Ras G12C-IN-1/CAS No.1629265-17-3 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.	price>
R-C-1351	Alpelisib(BYL719) CAS:1217486-61-7	Alpelisib(BYL-719)is a potent,selective, and orally active PI3Kα inhibitor. Alpelisib(BYL-719)shows efficacy in targeting PIK3CA-mutated cancer.Alpelisib (BYL-719)also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM,respectively.Antineoplastic activity.	price>
R-R-3051	KRASG12D-IN-1	KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.	price>

508509510511512513 514515516517518