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Catalog	name	Description	price
R-R-3023	Antineoplaston A10 CAS No.91531-30-5	Antineoplaston A10/CAS No.91531-30-5, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.	price>
R-C-1324	AZ7371 CAS：1494675-86-3	AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2-epimerase(DprE1;IC50=10nM),an enzyme involved in mycobacterial cell wall biogenesis.1 It inhibits wild-type M.smegmatis DprE1 and DprE1 harboring the drug-resistance mutation C394G(IC50=0.01 µM for both)but not the Y321H mutation (IC50=>10 µM).	price>
R-R-3024	KRpep-2d CAS No.2098181-84-9	KRpep-2d/CAS No.2098181-84-9 is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.	price>
R-C-1325	AVN-944 (VX-944) CAS：297730-17-7	AVN-944(VX-944)is an orally available,synthetic small molecule with potential antineoplastic activity.AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH),an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP),a purine molecule required for DNA and RNA synthesis.Inhibition of IMPDH deprives cancer cells of GTP,resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation,and the induction of apoptosis.AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only.IMPDH is overexpressed in some cancer cells,particularly in hematological malignancies.	price>
R-R-3025	MLS000532223 CAS No.16616-39-0	MLS000532223/CAS No.16616-39-0 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.	price>
R-C-1326	EHop-016 CAS：1380432-32-5	EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor.EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac,Rac-activated PAK1,lamellipodia formation,and cell migration.	price>
R-R-3026	RAS/RAS-RAF-IN-1 CAS No.2447039-81-6	RAS/RAS-RAF-IN-1/CAS No.2447039-81-6 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity.	price>
R-C-1327	FIPI CAS：939055-18-2	FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM,respectively.	price>
R-R-3027	SOS1-IN-15 CAS No.2793404-47-2	SOS1-IN-15 (Compound 37)/CAS No.2793404-47-2 is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer.	price>
R-C-1328	Onatasertib (CC 223) CAS：1228013-30-6	Onatasertib,also known as CC-223,is an orally available inhibitor of the mammalian target of rapamycin(mTOR)with potential antineoplastic activity.mTOR kinase inhibitor CC-223 inhibits the activity of mTOR,which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR,a serine/threonine kinase that is upregulated in a variety of tumors,plays an important role downstream in the PI3K/AKT/mTOR signaling pathway,which is frequently dysregulated in human cancers.	price>
R-R-3028	BI-0474 CAS No.2750570-55-7	BI-0474/CAS No.2750570-55-7 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.	price>
R-R-3029	Rac1 Inhibitor W56 TFA	Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.	price>
R-C-1330	MCC950 sodium（CP-456773 sodium; CRID3 sodium salt） CAS No. : 256373-96-3	MCC950 sodium(CP-456773 sodiumCRID3 sodium salt)is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.	price>
R-R-3030	Kobe2602 CAS No.454453-49-7	Kobe2602/CAS No.454453-49-7 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity.	price>
R-C-1331	Isoxazole 9 (ISX-9) CAS:832115-62-5	Isoxazole 9(Isx-9)is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells(NSPCs).Isoxazole 9(Isx-9)activates multiple pathways including TGF-βinduced epithelial–mesenchymal transition(EMT)signaling,canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.	price>
R-R-3031	SOS1-IN-14 CAS No.2793405-20-4	SOS1-IN-14/CAS No.2793405-20-4 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817).	price>
R-C-1332	JH-II127 CAS:1700693-08-8	JH-II-127 is a highly potent,selective,and brain penetrant LRRK2 inhibitor,with IC50 of 6.6 nM,2.2 nM,47.7 nM for LRRK2-wild-type,LRRK2-G2019S,LRRK2-A2016T.	price>
R-R-3032	K-Ras G12C-IN-4 CAS No.2376328-55-9	K-Ras G12C-IN-4/CAS No.2376328-55-9, compound 1, is a potent Covalent Inhibitor of KRASG12C.	price>
R-C-1333	NIBR189 CAS:1599432-08-2	NIBR-189 is a potent and selective EBI2(GPR183)receptor antagonist(IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively).NIBR-189 blocks migration of a monocyte cell line called U937,suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.	price>
R-R-3033	KRAS G12C inhibitor 14 CAS No.2349393-95-7	KRAS G12C inhibitor 14/CAS No.2349393-95-7 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.	price>

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