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Catalog	name	Description	price
R-R-3003	ML-097 CAS No.743456-83-9	ML-097 (CID-2160985)/CAS No.743456-83-9 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7.	price>
R-C-1304	IWP-L6 CAS：1427782-89-5	IWP-L6,also known as PORCN Inhibitor III and Wnt Pathway Inhibitor XIX,is a potent inhibitor of PORCN(EC50=0.5 nM).Porcupine is a member of the membrane-bound O-acyltransferase family of proteins.It catalyzes the palmitoylation of Wnt proteins,a process required for their secretion and activity.	price>
R-R-3004	KRA-533 CAS No.10161-87-2	KRA-533/CAS No.10161-87-2 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.	price>
R-C-1305	AV-412 CAS：451493-31-5	AV-412,also known as MP-412,is a second-generation,orally bioavailable dual kinase inhibitor with potential antineoplastic activity.EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2),which may result in the inhibition of tumor growth and angiogenesis,and tumor regression in EGFR/HER2-expressing tumors.This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors.EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.	price>
R-R-3005	RBC8 CAS No.361185-42-4	RBC8/CAS No.361185-42-4 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.	price>
R-C-1306	GFT-505 CAS：923978-27-2	Elafibranor,also known as GFT-505,is a dual PPARα/δagonist.Elafibranoris currently being studied for the treatment of cardiometabolic diseases including diabetes,insulin resistance,dyslipidemia,and non-alcoholic fatty liver disease (NAFLD).	price>
R-R-3006	Aliskiren Acid Impurity CAS No.:173400-13-0	Aliskiren Acid Impurity/CAS No.:173400-13-0 is a chemical compound associated with the drug Aliskiren, which is a direct renin inhibitor used primarily for the treatment of hypertension. This compound is a byproduct or degradation product that can form during the synthesis or storage of Aliskiren. Understanding and controlling impurities in pharmaceutical compounds is crucial for ensuring the safety and efficacy of the drug.	price>
R-C-1307	Prexasertib HCl (LY2606368) CAS：1234015-54-3	Prexasertib(LY2606368)is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L.For CHK2 and RSK,its IC50 values are 8 nM and 9 nM respectively in cell-free assay.	price>
R-R-3007	KRAS G12C inhibitor 19 CAS No.2649788-46-3	KRAS G12C inhibitor 19/CAS No.2649788-46-3 is a potent inhibitor of KRAS G12C. KRAS G12C inhibitor 19 significantly inhibits tumor growth (extracted from patent WO2021118877A1).	price>
R-C-1308	ODM201 CAS：1297538-32-9	ODM-201,also known as Darolutamide,ODM-201 is a full and high-affinity AR antagonist that,similar to second-generation antiandrogens enzalutamide and ARN-509,inhibits testosterone-induced nuclear translocation of AR.Importantly,ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies.	price>
R-R-3008	MRTX-EX185 formic	MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS. MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1309	WP1066 CAS:857064-38-1	WP1066 is a Stat3 inhibitor and JAK2 inhibitor.WP1066 is also a novel analogue of the JAK2 inhibitor AG490,in JAK2 V617F-positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera.WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3,signal transducer and activator of transcription-5,and extracellular signal-regulated kinase-1/2 pathways in a dose-and time-dependent manner.	price>
R-R-3009	KRAS inhibitor-3 CAS No.900897-56-5	KRAS inhibitor-3/CAS No.900897-56-5 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf.	price>
R-C-1310	Domatinostat (4SC-202） CAS：910462-43-0	Domatinostat(4SC-202 free base)is a selective class I HDAC inhibitor with IC50 of 1.20 μM,1.12 μM,and 0.57 μM for HDAC1,HDAC2,and HDAC3, respectively.It also displays inhibitory activity against Lysine specific demethylase 1(LSD1).	price>
R-R-3010	CID44216842 CAS No.1222513-26-9	CID44216842 (Cdc42-IN-1)/CAS No.1222513-26-9 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.	price>
R-R-3011	MCP110 CAS No.521310-51-0	MCP110/CAS No.521310-51-0 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors.	price>
R-C-1311	umi-77 CAS ：518303-20-3	UMI-77 is a selective Mcl-1 inhibitor,which shows high binding affinity to Mcl-1(IC50=0.31μM).UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM,showing selectivity over other members of anti-apoptotic Bcl-2 members.	price>
R-C-1312	SQ109 CAS：502487-67-4	SQ109 is a drug undergoing development for treatment of tuberculosis.SQ109 showed activity against both drug susceptible and Multi-drug-resistant tuberculosis bacteria,including Extensively drug-resistant tuberculosis strains. In preclinical studies SQ109 enhanced the activity of anti-tubercular drugs isoniazid and rifampin and reduced by >30% the time required to cure mice of experimental TB.SQ109 is being developed by OOO Infectex in Russia and by Sequella Inc internationally.I	price>
R-R-3012	ESI-08 CAS No.301177-43-5	ESI-08/CAS No.301177-43-5 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.	price>
R-C-1313	Ilomastat (GM6001, Galardin) CAS:142880-36-2	Ilomastat,also known as GM6001 and galardin,is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity.GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase,and anthrax lethal factor endopeptidase(LF) produced by the bacterium Bacillus anthracis.	price>

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