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Catalog	name	Description	price
R-C-1293	NS 11021 CAS:956014-19-0	NS-11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa,KCa1.1).BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.NS11021 enhances erectile responses in rats.	price>
R-R-2993	CE3F4 CAS No.143703-25-7	CE3F4/CAS No.143703-25-7 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.	price>
R-C-1294	KO143 CAS:461054-93-3	Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP)inhibitor.Ko 143 displays>200-fold selectivity over P-gp and MRP-1 transporters.	price>
R-R-2994	RMC-0331 CAS No.2488788-52-7	RMC-0331 (RM-023)/CAS No.2488788-52-7 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.	price>
R-C-1295	BAZ2-ICR CAS:1665195-94-7	BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. BAZ2-ICR has IC50(BAZ2A)=130 nM;IC50(BAZ2B)=180 nM;logD=1.05;solubility 25 mM (D2O)and F=70%.	price>
R-R-2995	RAS inhibitor Abd-7 CAS No.2351843-48-4	RAS inhibitor Abd-7/CAS No.2351843-48-4, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.	price>
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>
R-C-1297	Ceralasertib (AZD6738) CAS:1352226-88-0	Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.	price>
R-R-2997	8-CPT-2Me-cAMP sodium CAS No.634207-53-7	8-CPT-2Me-cAMP sodium/CAS No.634207-53-7 is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.	price>
R-C-1298	SBI0206965 CAS:1884220-36-3	SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor.Many tumors become addicted to autophagy for survival,suggesting inhibition of autophagy as a potential broadly applicable cancer therapy.SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells,regulating autophagy and cell survival.	price>
R-R-2998	MLS-573151 CAS No.10179-57-4	MLS-573151 (MLS000573151)/CAS No.10179-57-4 is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42.	price>
R-C-1299	SC79 CAS:305834-79-1	SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation,in the cytosol,by upstream kinases.SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head.SC-79 injections inhibited alcohol-induced osteonecrosis.Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.	price>
R-R-2999	AZA1 CAS No.1071098-42-4	AZA1/CAS No.1071098-42-4 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.	price>
R-C-1300	TAS-301 CAS:193620-69-8	TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery.TAS-103 inhibits smooth muscle cell migration and proliferation.TAS-103 inhibits intimal thickening after balloon injury to rat carotid arteries.TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.TAS-103 inhibits calcium-dependent signal transduction and cytoskeletal reorganization.	price>
R-R-3000	GGTI298 CAS No.180977-44-0	GGTI298/CAS No.180977-44-0 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.	price>
R-C-1301	TP-434 (Eravacycline) CAS：1207283-85-9	TP-434 is a novel,broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.	price>
R-R-3001	HJC0197 CAS No.1383539-73-8	HJC0197/CAS No.1383539-73-8 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.	price>
R-C-1302	cambendazol CAS：26097-80-3	Cambendazol is an antihelmintic that,at a dose of 50 mg/kg/day in mice, eradicates S.ratti adult worms from intestine and S.stercoralis larva from muscle.It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2µM.	price>
R-R-3002	CCG-100602 CAS No.1207113-88-9	CCG-100602/CAS No.1207113-88-9 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF.	price>
R-C-1303	CYC-116 CAS：693228-63-6	Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2(VEGFR2),resulting in disruption of the cell cycle,rapid cell death, and the inhibition of angiogenesis.	price>

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