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Catalog	name	Description	price
R-C-1283	IKK16 CAS:873225-46-8	IKK-16(IKK Inhibitor VII)is a selective IκB kinase(IKK)inhibitor for IKK-2,IKK complex and IKK-1 with IC50 of 40 nM,70 nM and 200 nM in cell-free assays, respectively.IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.	price>
R-R-2983	Pan-RAS-IN-1 CAS No.1835283-94-7	Pan-RAS-IN-1/CAS No.1835283-94-7 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.	price>
R-C-1284	Andarine CAS：401900-40-1	Andarine(GTx-007,S-4)is a selective non-steroidal androgen receptor(AR)agonist with Ki of 4 nM,tissue-selective for anabolic organs.	price>
R-R-2984	BDP9066 CAS No.2226507-04-4	BDP9066/CAS No.2226507-04-4 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.	price>
R-C-1285	Testolone (RAD140) CAS：1182367-47-0	Testolone(RAD140)is a potent,orally bioavailable,nonsteroidal selective androgen receptor modulator with Ki value of 7 nM as well as good selectivity over other steroid hormone nuclear receptors.	price>
R-R-2985	CCG-222740 CAS No.1922098-69-8	CCG-222740/CAS No.1922098-69-8 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.	price>
R-C-1286	SR9009 CAS：1379686-30-2	SR9009 is a rev-ErbA agonist.It increases the constitutive repression of genes regulated by Rev-ErbA with a half-maximum inhibitory concentration(IC50)=670 nM for Rev-ErbAαand IC50=800 nM for Rev-ErbAβ.	price>
R-R-2986	PROTAC K-Ras Degrader-1 CAS No.2378258-52-5	PROTAC K-Ras Degrader-1 (Compound 518)/CAS No.2378258-52-5 is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells.	price>
R-C-1287	YK11 CAS：1370003-76-1	YK-11 is a synthetic,steroidal selective androgen receptor modulator(SARM).It is a gene-selective partial agonist of the androgen receptor(AR)and does not induce the physical interaction between the NTD/AF1 and LBD/AF2(known as the N/C interaction),which is required for full transactivation of the AR.The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone(DHT)in this regard.	price>
R-R-2987	ML-099 CAS No.496775-95-2	ML-099 (CID-888706)/CAS No.496775-95-2 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A.	price>
R-C-1288	Ibutamoren (MK-677) CAS：159634-47-6	Ibutamoren,also known as MK-677(L-163,191),is a drug which acts as a potent, orally active growth hormone secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin.	price>
R-R-2988	Digeranyl bisphosphonate CAS No.878143-03-4	Digeranyl bisphosphonate (DGBP)/CAS No.878143-03-4 is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.	price>
R-C-1289	Entospletinib (GS-9973) CAS：1229208-44-9	Entospletinib,also known as GS-9973,is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.In Phase II clinical trials,Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.	price>
R-R-2989	Pan KRas-IN-1 CAS No.2791263-84-6	Pan KRas-IN-1/CAS No.2791263-84-6 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.	price>
R-C-1290	Filgotinib (GLPG0634) CAS：1206161-97-8	Filgotinib,also known as GLPG0634,is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis(RA)and Crohn is disease.It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1-over JAK2-dependent signaling.GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.	price>
R-R-2990	BQU57 CAS No.1637739-82-2	BQU57/CAS No.1637739-82-2 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.	price>
R-C-1291	Fimepinostat (CUDC-907) CAS：1339928-25-4	Fimepinostat(CUDC-907)potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10,respectively.	price>
R-R-2991	CCG-203971 CAS No.1443437-74-8	CCG-203971/CAS No.1443437-74-8 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent.	price>
R-C-1292	Vacquinol-1 CAS# 5428-80-8	Vacquinol-1,also known as NSC 13316,is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration.In glioblastoma cells,Vacquinol-1 targets macropinocytosis,a cellular process that will not lead to cell death in normal cells.	price>
R-R-2992	Rasarfin CAS No.674359-73-0	Rasarfin/CAS No.674359-73-0 is a dual Ras and ARF6 inhibitor.	price>

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