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Catalog	name	Description	price
R-C-1106	PQ401 CAS：196868-63-0	PQ401 is an inhibitor of insulin-like growth factor 1 receptor(IGF-1R).1 It inhibits autophosphorylation of the recombinant IGF-1R kinase domain(IC50=<1 μM)in a cell-free assay as well as IGF-1-stimulated IGF-1R autophosphorylation in MCF-7 cells(IC50=12μM).PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.2 It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro(IC50=6μM)and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.1 PQ401 also has antimalarial activity against the P.	price>
R-R-2806	Liraglutide CAS No.204656-20-2	Liraglutide/CAS No.204656-20-2 is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.	price>
R-C-1107	BMS794833 CAS：1174046-72-0	BMS-794833 is a potent ATP competitive inhibitor of Met(cMet)/VEGFR2 with IC50 of 1.7 nM/15 nM,also inhibits Ron,Axl and Flt3 with IC50 of <3 nM;a prodrug of BMS-817378.	price>
R-R-2807	NN1177 TFA	NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice.	price>
R-C-1108	ANA-12 CAS： 219766-25-3	ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites,respectively.	price>
R-R-2808	Emicerfont CAS No.786701-13-1	Emicerfont/CAS No.786701-13-1 is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.	price>
R-C-1109	ITD1 CAS:1099644-42-4	ITD 1 is an inhibitor of TGF-β(IC50=0.85 µM).It is selective for TGF-β in an SBE4/Smad reporter assay,providing 83% inhibition when used at a concentration of 2.5 µM,over activin A,which is inhibited by 51% when used at the same concentration.ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation.It stimulates differentiation of mouse embryonic stem cells (mESCs)into cardiomyocytes.	price>
R-R-2809	GLP-1(7-36), amide acetate CAS No.1119517-19-9	GLP-1(7-36), amide acetate/CAS No.1119517-19-9 is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.	price>
R-C-1110	MK0822 CAS：603139-19-1	Odanacatib is a potent,selective,and neutral inhibitor of cathepsin K(IC50s=0.2 and 1 nM for human and rabbit enzymes,respectively),a protease involved in osteoclastic bone resorption.It demonstrates high selectivity for cathepsin K over cathepsins B,L,and S.Formulations containing odanacatib reduce bone resorption,with lesser reductions in bone formation,resulting in increased bone mineral density.	price>
R-R-2810	Orforglipron CAS No.2212020-52-3	Orforglipron (LY3502970) (GLP-1 receptor agonist 1)/CAS No.2212020-52-3 is a GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.	price>
R-C-1111	Sunitinib (SU 11248) CAS：557795-19-4	Sunitinib(SU 11248)is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ,respectively.Sunitinib, an ATP-competitive inhibitor,effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.	price>
R-R-2811	MK 0893 CAS No.870823-12-4	MK 0893/CAS No.870823-12-4 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.	price>
R-C-1112	ML234 CAS: 1222800-79-4	ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.	price>
R-R-2812	Adomeglivant CAS No.1488363-78-5	Adomeglivant (LY2409021)/CAS No.1488363-78-5 is a potent, selective glucagon receptor (GluR) allosteric antagonist. Adomeglivant is widely used in the research for type 2 diabetes mellitus.	price>
R-C-1113	AC710 CAS:1351522-04-7	AC710 is a potent,orally active,and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity.	price>
R-R-2813	GLP-1(7-37) acetate CAS No.1450806-98-0	GLP-1(7-37) acetate/CAS No.1450806-98-0 is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.	price>
R-C-1114	AC5216 CAS：226954-04-7	Emapunil(AC-5216,18 kiloDalton Translocator Protein,XBD173)is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO)ligand. Emapunil(AC-5216)showes high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50 of 3.04 nM and 2.73 nM at rat glioma cells and human glioma cells,respectively.	price>
R-R-2814	Semaglutide TFA	Semaglutide TFA, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide TFA has the potential for type 2 diabetes treatment.	price>
R-C-1115	SD208 CAS：627536-09-8	SD-208 is a potent,orally active ATP-competitive transforming growth factor-β receptor 1(TGF-βRI)inhibitor(IC50=49 nM);displays>100-fold and>17-fold selectivity over TGF-βRII and other common kinases respectively.	price>
R-R-2815	BETP CAS No.1371569-69-5	BETP/CAS No.1371569-69-5 is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively.	price>

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