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Catalog	name	Description	price
R-R-2451	GSK046 CAS No.2474876-09-8	GSK046 (iBET-BD2)/CAS No.2474876-09-8 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity.	price>
R-C-752	C7280948 cas:587850-67-7	C-7280948 is a selective and potent protein methyltransferase1(PRMT1)inhibitor with an IC50 value of 12.75 μM.	price>
R-R-2452	dTRIM24 CAS No.2170695-14-2	dTRIM24/CAS No.2170695-14-2 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.	price>
R-C-753	CVT-10216 cas:1005334-57-5	CVT-10216 is a highly selective,reversible aldehyde dehydrogenase-2(ALDH-2)inhibitor with an IC50 of 29 nM.CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM.CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.	price>
R-R-2453	CPI-637 CAS No.1884712-47-3	CPI-637/CAS No.1884712-47-3 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.	price>
R-C-754	GNF-5 cas:778277-15-9	GNF-5,an analogue of GNF-2 with improved pharmacokinetic properties,is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).	price>
R-R-2454	I-BRD9 CAS No.1714146-59-4	I-BRD9/CAS No.1714146-59-4 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.	price>
R-C-755	PU-H71 cas:873436-91-0	PU-H71(NSC 750424)is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.	price>
R-R-2455	MI-3454 CAS No.2134169-43-8	MI-3454/CAS No.2134169-43-8 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis.	price>
R-C-756	EPZ5676 cas:1380288-87-8	Pinometostat(EPZ5676)is an S-adenosyl methionine(SAM)competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested,inhibits H3K79 methylation in tumor.	price>
R-R-2456	IACS-9571 hydrochloride CAS No.2319611-93-1	IACS-9571 (ASIS-P040) hydrochloride/CAS No.2319611-93-1 is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.	price>
R-C-757	KPT185 cas:133315-73-7	KPT185 is a selective CRM1 inhibitor.KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM,and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.	price>
R-R-2457	VZ185 CAS No.2306193-61-1	VZ185/CAS No.2306193-61-1 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.	price>
R-C-758	Romidepsin (FK228, Depsipeptide) cas:128517-07-7	Romidepsin(FK 228)is a Histone deacetylase(HDAC)inhibitor with anti-tumor activities.Romidepsin(FK 228)inhibits HDAC1,HDAC2,HDAC4,and HDAC6 with IC50s of 36 nM,47 nM,510 nM and 1.4 μM,respectively.Romidepsin(FK 228)is produced by Chromobacterium violaceum,induces cell G2/M phase arrest and apoptosis.	price>
R-R-2458	(R)-(-)-JQ1 Enantiomer CAS No.1268524-71-5	(R)-(-)-JQ1 Enantiomer/CAS No.1268524-71-5 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.	price>
R-C-759	LX1606 cas:1033805-22-9	LX 1606 is an orally bioavailable,small-molecule,tryptophan hydroxylase(TPH) inhibitor with potential antiserotonergic activity.	price>
R-R-2459	GNE-049 CAS No.1936421-41-8	GNE-049/CAS No.1936421-41-8 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively.	price>
R-C-760	sgc0946 CAS No. 1561178-17-3	SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM;selectively kill mixed lineage leukaemia cells.	price>
R-R-2460	FHT-1015 CAS No.2368903-18-6	FHT-1205/CAS No.2368903-18-6 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM (WO2020160180A1; compound 67).	price>
R-C-761	SKLB1002 cas:1225451-84-2	SKLB1002 is a new potent VEGFR2 inhibitor,which could significantly inhibit HUVEC proliferation,migration,invasion,and tube formation.	price>

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