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Catalog	name	Description	price
R-C-601	Rabeprazole sodium cas:117976-90-6	Rabeprazole sodium (LY307640 sodium)is a second-generation proton pump inhibitor(PPI)that irreversibly inactivates gastric H+/K+-ATPase.Rabeprazole sodium induces apoptosis.Rabeprazole sodium acts as an uridine nucleoside ribohydrolase(UNH)inhibitor with an IC50 of 0.3 μM.Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.	price>
R-R-2301	Ifidancitinib CAS No.1236667-40-5	Ifidancitinib (ATI-50002)/CAS No.1236667-40-5 is a potent and selective inhibitor of JAK kinases 1/3. Ifidancitinib can be used in studies of allergies, asthma and autoimmune diseases.	price>
R-C-602	CGK733 cas:905973-89-9	CGK733,a thiourea-containing compound,was originally identified as a specific inhibitor of ATR and ATM kinases (IC50=~200 nM).In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival,resulting in cell death.	price>
R-R-2302	Protosappanin A CAS No.102036-28-2	Protosappanin A (PTA)/CAS No.102036-28-2, an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.	price>
R-C-603	vx809 cas:936727-05-8	VX-80(Lumacaftor,VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR)maturation,EC50 of 0.1 μM in fisher rat thyroid cells.	price>
R-R-2303	Brepocitinib CAS No.1883299-62-4	Brepocitinib (PF-06700841)/CAS No.1883299-62-4 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.	price>
R-C-604	PR-619 cas:2645-32-1	PR-619 is a cell-permeable,reversible,and broad-spectrum inhibitor of the deubiquitinylating enzymes(DUBs).	price>
R-R-2304	TCS 21311 CAS No.1260181-14-3	TCS 21311 (NIBR3049)/CAS No.1260181-14-3 is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.	price>
R-C-605	Belinostat cas:414864-00-9	Belinostat(PXD101,NSC726630,PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay,with activity demonstrated in cisplatin-resistant tumors.Belinostat(PXD101)induces autophagy.	price>
R-R-2305	JAK2-IN-7 CAS No.2593402-36-7	JAK2-IN-7/CAS No.2593402-36-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities.	price>
R-C-606	SNS-314 cas: 1146618-41-8	SNS-314 is a potent and selective inhibitor of Aurora A,Aurora B and Aurora C with IC50 of 9 nM,31 nM,and 3 nM,respectively.It is less potent to Trk A/B, Flt4,Fms,Axl,c-Raf and DDR2.	price>
R-R-2306	JAK-IN-5 hydrochloride CAS No.2751323-21-2	JAK-IN-5 hydrochloride/CAS No.2751323-21-2 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.	price>
R-C-607	QNZ (EVP4593) cas:545380-34-5	QNZ(EVP4593)shows strong inhibitory effects on NF-κB transcriptional activation and TNF-αproduction with IC50s of 11 and 7 nM,respectively.QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.	price>
R-R-2307	BI-1622 CAS No.2681392-19-6	BI-1622/CAS No.2681392-19-6 is an orally active, potent and highly selective HER2 (ERBB2) inhibitor, with an IC50 of 7 nM. BI-1622 shows greater than 25-fold selectivity over EGFR. BI-1622 shows high antitumor efficacy in vivo in xenograft mouse tumor models with engineered H2170 and PC9 cells and had a favorable agent metabolism and pharmacokinetics profile.	price>
R-C-608	SU11274 cas:658084-23-2	SU11274(PKI-SU11274)is a selective Met(c-Met)inhibitor with IC50 of 10 nM in cell-free assays,no effects on PGDFRβ,EGFR or Tie2.SU11274 induces autophagy,apoptosis and cell cycle arrest.	price>
R-R-2308	JAK2/FLT3-IN-1 TFA CAS No.2928093-29-0	JAK2/FLT3-IN-1 (TFA)/CAS No.2928093-29-0 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity.	price>
R-C-609	p005672HCL cas:1035979-44-2	P5091(P005091)is a selective and potent inhibitor of ubiquitin-specific protease 7(USP7)with EC50 of 4.2 μM and the closely related USP47.	price>
R-R-2309	PF-06263276 CAS No.1421502-62-6	PF-06263276 (PF 6263276)/CAS No.1421502-62-6 is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.	price>
R-C-610	PLX4720 cas:918505-84-7	PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay,equally potent to c-Raf-1(Y340D and Y341D mutations),10-fold selectivity for B-RafV600E than wild-type B-Raf.	price>
R-R-2310	WHI-P97 CAS No.211555-05-4	WHI-P97/CAS No.211555-05-4 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo.	price>

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