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R-R-0900 Histatin-3 Histatin-3/CAS No.112844-49-2, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM. price>
R-FA-0017 Methacrylate-PEG-FA Methacrylate -Polyethylene glycol--Folate, Methacrylate-PEG-FA, FA-PEG-Methacrylate from ruixi Methacrylate-Polyethylene glycol--folic acid.The PEG moiety in the heterofunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. Folic acid functionalized substrates have been used for targeted drug delivery, imaging, and bio-assay development. price>
R-CT-070 Me-tetrazine-ICG S-tetrazine can produce stable covalent bonds through-4-2-Diels alder cycloaddition reactions with olefins with high tension,such as trans cyclooctene,norbornene and cyclopropene.No copper catalyst or high temperature is needed for this reaction. This is a biorthogonal reaction with excellent kinetics and selectivity.We can provide such products as methoxy tetrazine ICG. price>
R-R-0901 Norbiotinamine Norbiotinamine/CAS No.173401-47-3 is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. price>
R-FA-0018 IA-PEG-FA Iodoacetate -Polyethylene glycol--Folate,IA-PEG-FA,FA-PEG-IA from ruixi Iodoacetate-Polyethylene glycol--folic acid.Iodoacetate-PEG--Folate is a hetero-functional peg derivative. One end of PEG is connected with Folate , the other end is connected with Iodoacetate. Pegylated folic acid has relatively good water solubility and bioactivity. Folic acid functionalized substrates have been used for targeted drug delivery, imaging, and bioassay development. price>
R-CT-071 Me-tetrazine-Disulfo-ICG New indocyanine green is a kind of near infrared dyes.As a near-infrared fluorescent dye,it has important research value in life science and biomedical research,and is a common fluorescent marker in drug research.Tetrazine is a six membered heterocyclic compound with four nitrogen atoms.We can provide such products as methoxy tetrazine disulfo ICG. price>
R-R-0902 UDP-GalNAc disodium UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium/CAS No.108320-87-2 is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. price>
R-FA-0019 Chloride-PEG-FA Chloride -Polyethylene glycol--Folate, Chloride-PEG-FA, FA-PEG- Chloride from ruixi Chloride-Polyethylene glycol--folic acid.Chloride-PEG--Folate is a hetero-functional peg derivative. One end of PEG is connected with Folate , the other end is connected with Iodoacetate. Pegylated folic acid has relatively good water solubility and bioactivity. Folic acid functionalized substrates have been used for targeted drug delivery, imaging, and bioassay development. price>
R-CT-072 TAMRA-5-Tetrazine Rhodamine is a commonly used red fluorescent dye tracer,which is used to stain cells,tissues,biomarkers or nanoparticles.It has a peak fluorescence emission at 572-575 nm.Tetrazine can be used for biorthogonal reactions in many bioimaging and conjugation applications.At present,it has been widely used in protein specific site function interpretation,subcellular structure selective labeling,drug targeted delivery,in vivo animal molecular imaging and preparation of biocompatible materials.Ruixi provide TAMRA-5-tetrazine. price>
R-R-0903 Antalarmin hydrochloride Antalarmin (hydrochloride)/CAS No.220953-69-5 is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome. price>
R-MU-001 4arm-PEG-CHO 4 arm-Polyethylene glycol-CHO, 4 arm-PEG-CHO, CHO-PEG-4 arm from ruixi 4-arm Poly(ethylene glycol) aldehyde (4-Arm PEG-CHO) from Advanced BioChemicals (ABC) are high quality multi-arm PEG derivatives with aldehyde at each terminal of the four arms that reacts with amine and N-terminal peptide and protein to form an imine containing a C=N double bond which can be further reduced to a more stable C-N bond.The total molecular weight of 4-Arm PEGs is the sum of the molecular weights of all four arms. price>
R-CT-073 TAMRA-PEG4-Methyltetrazine Rhodamine is a commonly used red fluorescent dye tracer, which is used to stain cells,tissues, biomarkers or nanoparticles.It has a peak fluorescence emission at 572-575 nm.Tetrazine can be used for biorthogonal reactions in many bioimaging and conjugation applications.At present,it has been widely used in protein specific site function interpretation, subcellular structure selective labeling,drug targeted delivery,in vivo animal molecular imaging and preparation of biocompatible materials.Ruixi provide TAMRA-PEG4-Methyltetrazine. price>
R-R-0904 Almorexant hydrochloride Almorexant (ACT 078573) hydrochloride/CAS No.913358-93-7 is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis. price>
R-MU-002 4arm-PEG-Hydrazide 4 arm-Polyethylene glycol-Hydrazide,4 arm-PEG-Hydrazide ,Hydrazide-PEG-4 arm from ruixi Methoxy PEG Hydrazide (MPEG Hydrazine or MPEG Hydrazide) from ruixibiotech is a high quality aldehyde reactive PEG, ketone reactive PEG, and carboxyl reactive PEG. The hydrazide group is carbonyl reactive and it is usually employed in PEGylation of glycosylated sites of proteins. price>
R-CT-074 Methyltetrazine-PEG4-azide Azide is one of several compounds containing-N3 group,which is derived from azide acid (HN3).There are two kinds of organic azides,alkyl and aryl azides,and acyl azides (rcon3).Polyethylene glycol is an adduct of polyethylene oxide and water.It can be used as plasticizer,softener,humidifier,lubricant,ointment and medicine. Ruixi can provide Methyltetrazine-PEG4-azide. price>
R-R-0905 Trastuzumab deruxtecan Trastuzumab deruxtecan (DS-8201a)/CAS No.1826843-81-5 is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer. price>
R-MU-003 4arm-peg-LA 4 arm-Polyethylene glycol-Lipoic acid,4 arm-peg-LA ,LA-peg-4 arm from ruixi 4-arm polyethylene glycol Lipoic acid is a multi-arm polyethylene glycol derivative with Lipoic acid at each end of the four arms connected to a pentaerythritol nucleus.Lipoic acid can be used to bind to metallic particle or film surface with its -S-S-bond, thank its high affinity . It has been 5-widely used for gold nanoparticles and quantum dots surfaces. price>
R-CT-075 Me-Tetrazine-NHBoc Methyl group is composed of carbon and hydrogen.An electrically neutral monovalent group left in a methane molecule after the removal of one hydrogen atom.Tetrazine is a six membered heterocyclic compound with four nitrogen atoms.The protective group usually protects the hydroxyl group,amino group and other groups.Ruixi can provide such products Me-Tetrazine-NHBoc. price>
R-R-0906 Allisartan isoproxil Allisartan isoproxil (ALS-3)/CAS No.947331-05-7 is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1. Allisartan isoproxil is also an antihypertensive agent. Allisartan isoproxil may inhibit angiotensin-aldosterone system and oxidative stress. Allisartan isoproxil lowers blood pressure and protects the organs, preventing cerebrovascular damage. Allisartan isoproxil (80-320 mg/kg/d) has shown toxicity in rat models by targeting liver organs. price>
R-MU-004 4arm-peg-Tosylate 4 arm-Polyethylene glycol-Tosylate,4 arm-peg-Tosylate,Tosylate-peg-4 arm from ruixi 4-Arm PEG-Tosylate is a multiarm PEG derivative with tosyl or toluenesulfonyl groups at each terminal of the four arms connected to one pentaerythritol core. Tosylate is a very good leaving group for neucleophilic substitution reaction. 4-Arm PEG-Mesylate or mesyl may be offered through custom synthesis. price>