ZM323881 cas:324077-30-7

ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGF-R2 tyrosine phosphorylation(IC50Vascular endothelial growth factor(VEGF) increases vascular permeability and angiogenesis in many pathological conditions, such as cancer,arthritis,and diabetes.VEGF activates VEGF-Receptor 1(VEGF-R1)and VEGF-Receptor 2(VEGF-R2)that autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular permeability.ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase.

msds---ZM323881