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Tuspetinib CAS No.2294874-49-8
Tuspetinib CAS No.2294874-49-8
| Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
|---|---|---|---|---|
| R-R-1409 | 5mg | 380.00 | + Add to cart |
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| R-R-1409 | 10mg | 620.00 | + Add to cart |
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Product description
Tuspetinib (HM43239)/CAS No.2294874-49-8 is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells.
| Appearance | N/A |
|---|---|
| Molecular Weight | 501.07 |
| Purity | >90% |
| CAS | 2294874-49-8 |
| Formula | C29H33ClN6 |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
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