TPP-PDL10

TPP-Right-handed polylysine/TPP-Poly-D-Lysine10/TPP-PDL10 can be designed as a carrier for drugs or gene therapy agents, specifically targeting mitochondria within cells. This targeting is particularly beneficial for treating diseases where mitochondrial dysfunction is implicated, such as neurodegenerative diseases, cancer, and metabolic disorders.

The positive charge from both TPP and Poly-D-Lysine may improve the uptake of the conjugate into cells through endocytosis. This characteristic can be harnessed for efficient delivery of therapeutic proteins, nucleic acids (like siRNA or DNA), or any hydrophilic compounds that have poor cellular permeability.

If the TPP-Poly-D-Lysine conjugate is tagged with a fluorescent dye, it can be utilized for imaging mitochondria in live cells. This can help in studies aimed at elucidating mitochondrial dynamics, morphology, and their role in various cellular processes.

msds of TPP-Poly-D-Lysine10