Peptide P60

Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3.Peptide P60 has demonstrated potential of inhibiting the immunosuppressive activity of murine and human derived regulatory T-cells (Tregs) and enhances the effector T-cell stimulation in vitro by binding to regulatory T-cells specific forkhead/winged helix transcription factor 3 (FOXP3). Peptide P60 can enter the cells to inhibit FOXP3 nuclear translocation and activity on other transcription factors. In vitro, peptide P60 (100 uM) inhibited murine and human-derived Treg and improved effector T cell stimulation.

MSDS of Peptide P60