MTX@ZIF-8 nanoparticles

Methotrexate (MTX)-loaded ZIF-8/Methotrexate@ZIF-8 nanoparticles/ Methotrexate@zeolitic imidazolate framework-8 nanoparticles/MTX@ZIF-8 nanoparticles is a pH sensitive biomimetic drug delivery system. In vitro studies have shown that effective drug release can be achieved in acidic environments.MTX@ZIF-8 Nanoparticles have good thermal stability and minimal weight loss at temperatures up to 400℃.Research shows, MTX@ZIF-8 nanoparticles showed high (drug loading efficiency)DLE (~70%) and EE(encapsulation efficiency) (~82%).MTX@ZIF-8 nanoparticles for effective RA(Rheumatoid arthritis) treatment. 

The encapsulation of MTX in ZIF-8 was verified by UV-Vis spectroscopy (Fig. A)

MTX and MTX@ZIF-8 showed the same characteristic absorption peaks at 258 and 302 nm ,indicating the successful loading of MTX into the ZIF-8 structure.

Moreover, MTX@ZIF-8 showed a similar XRD pattern to ZIF-8, suggesting the negligible effect of MTX on the crystal structure of ZIF-8 (Fig. B).

TGA measurements revealed that ZIF-8 and MTX@ZIF-8 had good thermal stability, with little weight loss at temperatures up to 400 °C (Fig. C)

TEM, the roughly spherical shape of bare ZIF-8 changed only slightly after drug loading (Fig. G, H).

msds of MTX@ZIF-8 nanoparticles