MTX-PEI25k (Branched chain)

PEI-MTX,MTX-PEI,Polyethyleneimine(PEI)is a cationic polymer,it widely used as a gene delivery vector.PEI can complex with nucleic acids,protect them from degradation,and facilitate their intracellular delivery.Additionally,PEI possesses protonatable amino groups that enable endosomal escape, enhancing gene expression.MTX refers to methotrexate, a chemotherapy drug that inhibits the synthesis of nucleotides,leading to the suppression of DNA replication and cell proliferation.PEI-MTX conjugate combines the beneficial properties of both PEI and MTX for targeted drug delivery.The MTX moiety in the conjugate acts as a targeting ligand that can specifically bind to folate receptors,which are frequently overexpressed on the surface of cancer cells.

msds---MTX-PEI25k