Polypeptide GE11 is a small molecule polypeptide obtained by phage peptide library screening technology,which is composed of 11 amino acids(YHWYGYTPQNVI). Compared with macromolecular natural ligands, polypeptide ligands have the advantages of small relative molecular weight and low immunogenicity;Easy to spread and high targeting, which can meet the requirements of targeted tumors;It has no effect on the growth of tumor cells.GE11 modified micelles targeted EGFR.The results showed that the prepared micelles actively targeted EGFR accelerated the drug uptake of cells,and EGFR was overexpressed on the surface of non-small cell lung cancer.Phospholipid micelles have good penetration into tumor tissue, and it is possible to obtain better drug aggregation effect in tumor tissue by introducing targeting them.

msds----GE11-polyethylene glycol750-DSPE