DSPE-PEG-AE105(D-Cha-F-s-r-Y-L-W-S)

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol is a PEG-modified lipids. It is a long circulating liposome membrane, formation of micelles in water dispersion, the critical micelle concentration (CMC) ratio of surfactant is 102 times lower, so the drug stability is better, even by hemodilution, can maintain the integrity of the micelle particle, has certain targeting, easy accumulation in solid tumors.It can couple various polypeptide groups.The AE105 peptide (D-Cha-F-s-r-Y-L-W-s) bound to the uPAR domain III ring 3 was coupled with DOTA. After labeling with 64Cu, the tracer was evaluated for microscopic PET imaging of uPAR expression in nurine xenotransplantation model (uPAR positive and uPAR negative).

msds----DSPE-PEG-AE105(D-Cha-F-s-r-Y-L-W-S)