DSPE-PEG350-pemetrexed

Pemetrexed is a folic acid antagonist.Pemetrexed inhibits thymidylate synthase(TS),dihydrofolate reductase(DHFR)and glycine nucleotide formyl transferase (GARFT).DSPE-PEG,It is a long circulating liposome membrane,formation of micelles in water dispersion,the critical micelle concentration(CMC)ratio of surfactant is 102 times lower,so the drug stability is better,even by hemodilution,can maintain the integrity of the micelle particle,has certain targeting,easy accumulation in solid tumors.