CRVLRSGSC(CC Looping)-peg-Chol

CRVLRSGSC-(CC Looping)-PEG-Chol/Cholesterol-peg-CRVLRSGSC(CC Looping) is a targeted amphiphilic conjugate composed of a cyclic peptide (CRVLRSGSC) linked via a polyethylene glycol (PEG) spacer to cholesterol (Chol).
The CRVLRSGSC peptide contains two cysteine residues that form an intramolecular disulfide bond (CC looping), stabilizing its cyclic structure for enhanced receptor selectivity and proteolytic resistance. The PEG linker provides solubility and flexibility, while cholesterol serves as a lipophilic anchor for membrane or liposome incorporation.
Applications:
Targeted liposome or nanoparticle design: Enhances binding to specific receptors associated with the CRVLRSGSC motif;
Drug delivery: Facilitates receptor-mediated uptake into specific tissues or cells;
Membrane functionalization: Used to decorate lipid bilayers with targeting ligands;
Theranostic systems: For coupling targeting peptides with imaging or therapeutic nanocarriers.

msds of CRVLRSGSC(CC Looping)-peg-Chol