c(RGDDYK)-PEG3400-DSPE

c(RGDDYK) is a model peptide targeting molecule,which can be modified on the surface of liposomes.The immunogenicity and related mechanism of peptide mediated targeting nanoparticles were systematically studied.After intravenous injection of c(RGDDYK) modified liposomes,a large number of antibodies were produced. Repeated injections resulted in the deposition of immune complexes with antibodies in liver,kidney and lung tissues,activating the complement system, releasing allergens and cytokines,resulting in hypersensitivity such as capillary leakage,alveolar protein deposition,inflammatory cell infiltration,kidney and liver congestion,resulting in hypothermia or death in mice.

msds---c(RGDDYK)-PEG3400-DSPE