ALW-II-41-27 CAS:1186206-79-0

ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor.pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo.ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively,these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant,EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors.

msds---ALW-II-41-27