Ac-Ile-Glu-Thr-Asp-AMC

Ac-Ile-Glu-Thr-Asp-AMC, Ac-IETD-AMC(CAS : 348079-17-4) is a fluorogenic substrate for Caspase 8 and Granzyme B. Caspase 8 is a cysteine protease involved in apoptosis induced by Fas and other stimuli. It is an attractive therapeutic target for a variety of degenerative disorders. Granzyme B is a serine protease found in cytotoxic T-cells and NK cells. It cleaves and activates several caspases involved in apoptosis.

MSDS of Ac-Ile-Glu-Thr-Asp-AMC