Product synthetic-chemistry-click-chemistry-dbco

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Catalog	name	Description	price
R-M1by-9084	2-3-cGAMP-DBCO conjugate	2-3-cGAMP-DBCO conjugate conjugate is an excellent component for developing 2-3-cGAMP probes for studying their biological activity and function.2-3-cGAMPhas been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, making it a cancer immunotherapy.	price>
R-M1by-9085	2,3-cGAMP-azide	2,3-cGAMP-azides are excellent reagents for coupling 2,3-cGAMP to alkyne modified biological targets such as proteins, peptides, and nucleic acids.In recent years, 2,3-cGAMP has attracted much attention as a potential target for treating diseases such as cancer and viral infections. Research has shown that immune checkpoint inhibitors are a cancer immunotherapy that can activate the immune system and enhance its efficacy. 2,3-cGAMP (cyclic GMP AMP) is a cyclic dinucleotide second messenger molecule that plays a crucial role in the innate immune system. It is synthesized by cGAS (cyclic GMP AMP synthase) in response to cytoplasmic DNA released by damaged or infected cells. Once synthesized, 2,3-cGAMP binds to the adapter protein STING (a stimulatory factor of the interferon gene) and triggers downstream signaling pathways, producing type I interferon and other cytokines, thereby generating an immune response against invading pathogens.	price>
R-M1-9154	DBCO-SS-AAKLVFFWHRSYYTWNLNT	DBCO-SS-AAKLVFFWHRSYYTWNLNT is commonly used in studies involving chemical biology, drug delivery, or bioconjugation, typically for linking specific molecules or groups to the peptide for various biological or chemical applications.	price>
R-M2-9299	Heparin-DBCO	Heparin-DBCO is typically designed for biomedical applications, particularly in drug delivery systems and biomarkers (to achieve specific cell targeting).	price>
R-M2-9300	Heparin-PEG4-DBCO	Heparin-PEG4-DBCO is likely utilized in developing novel drug delivery systems, molecules with specific biological activities, or for applications involving targeted peptides and more.	price>
R-M2-9343	DBCO-Alginate	DBCO-sodium alginate refers to a specific bioconjugation system where DBCO (Dibenzocyclooctyne) is conjugated to sodium alginate. This combination allows for the functionalization of sodium alginate with DBCO groups, enabling subsequent conjugation with azide-functionalized molecules via copper-free click chemistry. By linking DBCO to sodium alginate, researchers can create a platform for bioconjugation applications in various fields such as drug delivery, tissue engineering, and diagnostics, leveraging the specificity and efficiency offered by click chemistry reactions.	price>
R-M2-9365	NHS-PEG2k-TK-DBCO	NHS-PEG2k-TK-DBCO serves as a flexible tool in bioconjugation strategies for attaching molecules in a controlled and specific manner, often applied in areas like drug delivery, imaging, and diagnostics in biomedical research.	price>
R-M2-9396	DBCO-TK-MAL	DBCO-TK-MAL/Dibenzocyclooctyne-thioketal-maleimide is a multi-component molecule that comprises a cycloalkyne, a butyrate salt, and a maleimide group. This compound may be used to deliver bioactive molecules, drug payloads, or imaging dyes to specific biological targets with high specificity and low off-target effects.	price>
R-M2-9464	endo-BCN-GAL	The combination of endo-BCN with galactose(endo-BCN-galactose) can have several applications, especially in the fields of biochemistry and medicinal chemistry: The endo-BCN can react with azide-containing species through a rapid and selective click reaction. This feature allows researchers to label or modify galactose or galactose-containing biomolecules selectively, allowing for traceable modifications. By attaching bioactive molecules or drugs to galactose, researchers can create targeted drug delivery systems. Many cells have receptors that specifically recognize galactose, allowing for more precise targeting of therapies, especially in tissues where galactose is a more prevalent ligand. This compound could potentially be used to create biosensors. By incorporating it into a biosensor platform, it may be possible to detect specific interactions between galactose and its binding partners, with BCN facilitating easy coupling of labels or signal-generating groups.	price>
R-M-7081	DBCO-C6-NH2	DBCO-C6-NH2 is an analog of DBCO-NH2 with an extended 6-carbon atom spacer arm. The extended 6-carbon atom spacer arm improves its derivatization efficiency and the stability of the yielded conjugates. This spacer arm also improves solubility in organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. DBCO is commonly used for copper-free Click Chemistry reactions.	price>

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