|Exemestane (FCE 24304) CAS：107868-30-4
|Exemestane is a synthetic androgen analogue.Exemestane binds irreversibly to and inhibits the enzyme aromatase,thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
|Fluticasone propionate CAS：80474-14-2
|Fluticasone propionate,a potent topical anti-inflammatory corticosteroid,is a selective glucocorticoid receptor agonist,with an absolute affinity(KD)of 0.5 nM.Fluticasone propionate shows little or no activity at other steroid receptors.Anti-viral activity.
|APD668 is a potent,selective and orally active agonist of G-protein coupled receptor GPR119,with EC50s of 2.7nM and 33nM for hGPR119 and rGPR119, respectively.APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9(Ki=0.1μM).APD668 can be used for the research of steatohepatitis and diabetes.
|Trabectedin(Ecteinascidin 743;ET-743)is a tetrahydroisoquinoline alkaloid with potent antitumor activity.Trabectedin binds to the minor groove of DNA,blocks transcription of stress-induced proteins,induces DNA backbone cleavage and cancer cells apoptosis,and increases the generation of ROS in MCF-7 and MDA-MB-453 cells.
|U 73343 CAS:142878-12-4
|U-73343,works as a protonophore,is an inactive analog of U-73122 and can be used as a negative control.U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant.U-73122 is a phospholipase C(PLC)and 5-LO(5-lipoxygenase)inhibitor with an IC50 of 1-2.1µM for PLC.
|LYC-55716 CAS: 2055536-64-4
|Cintirorgon (LYC-55716)is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells,resulting in enhanced effector function,as well as decreased immunosuppression,resulting in decreased tumor growth,and improved survival.
|AZD-0284 CAS: 2101291-07-8
|AZD-0284 is a potent,selective,inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis.
|XY101 is a potent,selective,metabolically stable and orally available RORγ inverse agonist with an IC50 of 30nM and a Kd of 380nM.
|S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t(RORγt)inhibitor with an IC50 of 29nM.S18-000003 inhibits IL-17 production.
|SR3335(ML 176)is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220nM. Our products are only suitable for scientific research experiments, not for clinical experiments and human body.