Catalog name Description price
R-C-2258 Ailanthone CAS:981-15-7 Ailanthone(AIL,Δ13-Dehydrochaparrinone),a natural anti-hepatocellular carcinoma (HCC)component in Ailanthus altissima,induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27.Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway.Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. price>
R-C-1903 TC-G-1008 (GPR39-C3) CAS:1621175-65-2 TC-G-1008 is a GPR39(zinc receptor)agonist(EC50 values are 0.4 and 0.8nM for rat and human receptors respectively). price>
R-C-2387 Propafenone CAS:54063-53-5 Propafenone(SA-79)is an orally active sodium channel blocking agent and a beta-adrenoceptor(β-adrenergic receptor)antagonist.Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias. price>
R-C-2405 SR59230A CAS:174689-39-5 SR59230A is a blood-brain barrier penetrating,potent and selective antagonist of β3-adrenergic receptor with IC50 of 40nM,408nM,and 648nM for β3,β1,and β2 receptors,respectively. price>
R-C-2410 Nadolol CAS:42200-33-9 Nadolol(SQ-11725)is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2(OATP1A2).Nadolol has the the potential for high blood pressure,angina pectoris and vascular headaches research. price>
R-C-2415 Nicergoline CAS:27848-84-6 Nicergoline,an ergoline derivative ester of bromonicotinic acid,is a potent, selective and orally active antagonist of α1A-adrenoceptor.Nicergoline has vasodilator effects.Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer is disease. price>
R-C-2417 Olodaterol (BI 1744) CAS:868049-49-4 Olodaterol(BI 1744)is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation(Tiotropium/Olodaterol)for treating patients with chronic obstructive pulmonary disease(COPD). price>
R-C-2418 Guanabenz CAS:5051-62-7 Guanabenz(Acetate)(BR-750)is an alpha-2 selective adrenergic agonist used as an antihypertensive agent. price>
R-C-2490 GW-9508 CAS: 885101-89-3 GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40)and GPR120 agonist with pEC50s of 7.32 and 5.46,respectively.GW9508 shows ~100-fold selectivity for GPR40 over GPR120.GW9508 is inactive against other GPCRs,kinases,proteases,integrins and PPARs.GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium(KATP)channels opener. Anti-inflammatory and anti-atherosclerotic activities. price>
R-C-2529 Apalutamide (ARN-509) CAS:956104-40-8 Apalutamide(ARN-509 and JNJ-56021927)is an androgen receptor antagonist with potential antineoplastic activity.ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus.This prevents binding to and transcription of AR-responsive genes.This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. price>