Catalog name Description price
R-C-440 LY2157299 Galunisertib(LY2157299)is selective TGF-receptor kinase inhibitor.Galunisertib was found to inhibit the growth in an in vitro clonogenic assay in 6.3%(5/79)of the examined PDX. price>
R-C-498 LY2109761 cas:700874-71-1 LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay,respectively;shown to negatively affect the phosphorylation of Smad2.LY2109761 blocks autophagy and induces apoptosis. price>
R-C-549 GW788388 CAS: 452342-67-5 GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay,also inhibits TGF-βtype II receptor and activin type II receptor activities,but does not inhibit BMP type II receptor. price>
R-C-559 LY364947 cas:396129-53-6 LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM,and exhibits 7-fold selectivity over TGFβR-II. price>
R-C-570 SB431542 cas:301836-41-9 SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4,ALK5,and ALK7. price>
R-C-639 SB505124 cas:694433-59-5 SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5),ALK4 and ALK7(IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). price>
R-C-713 SB525334 cas:356559-20-1 SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5,TGF-βRI)(IC50=14.3 nM).Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. price>
R-C-1026 kartogenin CAS No. 4727-31-5 Kartogenin(KGN)is an inducer of differentiation of human mesenchymal stem cells into chondrocytes,with an EC50 of 100 nM. Kartogenin binds filamin A,disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ),and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.Kartogenin can be used for the research of osteoarthritis(OA). price>
R-C-1109 ITD1 CAS:1099644-42-4 ITD 1 is an inhibitor of TGF-β(IC50=0.85 µM).It is selective for TGF-β in an SBE4/Smad reporter assay,providing 83% inhibition when used at a concentration of 2.5 µM,over activin A,which is inhibited by 51% when used at the same concentration.ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation.It stimulates differentiation of mouse embryonic stem cells (mESCs)into cardiomyocytes. price>
R-C-1115 SD208 CAS:627536-09-8 SD-208 is a potent,orally active ATP-competitive transforming growth factor-β receptor 1(TGF-βRI)inhibitor(IC50=49 nM);displays>100-fold and>17-fold selectivity over TGF-βRII and other common kinases respectively. price>