Catalog name Description price
R-M-182 XPA Peptide Xeroderma pigmentosum group A-complementing protein (XPA) is involved in DNA excision repair by binding to damaged sites with various affinities depending on photoadduct and transcriptional state. Defects in XPA are a cause of xeroderma pigmentosum complementation group A characterized by solar sensitivity and skin cancer predisposition.XPA is a zinc finger protein, which plays a central role in nucleotide excision repair (NER). XPA interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in XPA cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. price>
R-M-183 WT1 Peptide WT1,Wilms tumor 1 Peptide has a potential role in transcriptional regulation by recognizing and binding to the DNA sequence 5-CGCCCCCGC-3. Defects in WT1 are the cause of nephropathy (Frasier and Denys-Drash syndromes) and genito-urinary dysplasia in Wilms tumor syndrome.Data on WT1 peptide vaccine-treated patients with immunological and/or clinical response have been accumulated. MDS and acute myeloid leukemia were the major target diseases to provide proof of concept for the therapeutic potential of the WT1 peptide vaccine. WT1 vaccination-induced clinical responses or usefulness were also shown for chronic myeloid leukemia, multiple myeloma, and acute lymphoblastic leukemia, as well as various types of solid cancers.Patients with hematologic malignancies have minimal residual disease after chemotherapy or allogeneic hematopoietic stem cell transplantation, which can be treated by WT1 peptide vaccine. price>
R-M-184 WRN Peptide Werner syndrome ATP-dependent helicase (WRN) is essential for the formation of DNA replication focal centers and associates with foci elements generating binding sites for RPA. Defects in WRN are a cause of Werner syndrome, a multiple age-related disorders, including atherosclerosis, cancer, diabetes and osteoporosis. price>
R-M-185 WNK4 Peptide Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII). price>
R-M-186 VHL Peptide VHL,Von Hippel Lindau is involved in the ubiquitination and subsequent proteasomal degradation of hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Defects in VHL are the cause of different types of cancers (pheochromocytoma, von Hippel-Lindau disease) and erythrocytosis. price>
R-M-187 TYRO10 (DDR2) Peptide TYRO10 (DDR2)Peptide,TYRO10(Discoidin Domain Receptor Tyrosine Kinase 2)Peptidefrom ruixi.TYRO10 (DDR2),Discoidin Domain Receptor Tyrosine Kinase 2 is a tyrosine kinase receptor for fibrillar collagen that mediates fibroblast migration and proliferation. TYRO10 contributes to cutaneous wound healing. price>
R-M-154 XPC Peptide Xeroderma pigmentosum group C-complementing protein (XPC) is involved in DNA excision repair by recognizing DNA damage and altering chromatin structure for damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C characterized by solar sensitivity and skin cancer predisposition. price>
R-M-279 TNF-alpha Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection. price>
R-M-281 TIMP-3 Peptide Tissue inhibitor of metalloproteinases 3 (TIMP-3) binds to metalloproteinases such as collagenases and irreversibly inactivates the proteases. TIMP-2 is involved in the extracellular matrix remodeling by binding to MMP-1, -2, -3, -7, -9, -13, -14 and -15. Defects in TIMP-3 are the cause of Sorsby fundus dystrophy (SFD), a macular disorder leading to vision loss. price>
R-M-1266 SYVN1 Peptide Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis. price>