Catalog name Description price
R-C-764 CZC54252 CAS:1191911-27-9 CZC54252 is a highly effective inhibitor of LRRK2.Its IC50 values for wild-type LRRK2 and mutant G2019S LRRK2 are 1.28 and 1.85 nm,respectively. price>
R-C-1078 GSK2578125A CAS:1285515-21-0 GSK2578215A is a potent and highly selective LRRK2 inhibitor,which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. price>
R-C-1121 SKF-86002 CAS:72873-74-6 SKF-86002 is an orally active p38 MAPK inhibitor,with anti-inflammatory,anti-arthritic and analgesic activities.SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. price>
R-C-1124 PF06447475 CAS:1527473-33-1 PF06447475 is a highly potent,selective,brain penetrant,and in vivo active LRRK2 kinase inhibitor.Leucine rich repeat kinase 2(LRRK2)has been genetically linked to Parkinson disease(PD)by genome-wide association studies(GWAS).The most common LRRK2 mutation,G2019S,which is relatively rare in the total population,gives rise to increased kinase activity.As such,LRRK2 kinase inhibitors are potentially useful in the treatment of PD. price>
R-C-1190 LRRK2-IN-1 CAS:1234480-84-2 LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2(G2019S)and LRRK2(WT),respectively. price>
R-C-1237 Spautin-1 CAS:1262888-28-7 Spautin-1 is a novel autophagy inhibitor,IM inhibited the growth of K562 cells with IC50 of 1.03μM.In contrast,co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. price>
R-C-1286 SR9009 CAS:1379686-30-2 SR9009 is a rev-ErbA agonist.It increases the constitutive repression of genes regulated by Rev-ErbA with a half-maximum inhibitory concentration(IC50)=670 nM for Rev-ErbAαand IC50=800 nM for Rev-ErbAβ. price>
R-C-1298 SBI0206965 CAS:1884220-36-3 SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor.Many tumors become addicted to autophagy for survival,suggesting inhibition of autophagy as a potential broadly applicable cancer therapy.SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells,regulating autophagy and cell survival. price>
R-C-1332 JH-II127 CAS:1700693-08-8 JH-II-127 is a highly potent,selective,and brain penetrant LRRK2 inhibitor,with IC50 of 6.6 nM,2.2 nM,47.7 nM for LRRK2-wild-type,LRRK2-G2019S,LRRK2-A2016T. price>
R-C-1410 CZC-25146 CAS:1191911-26-8 CZC-25146 is a second generation inhibitor of LRRK2 with excellent potency and selectivity.In a time-resolved fluorescence resonance energy transfer assay, CZC-25146 shows potent inhibition of both recombinant human wild type LRRK2 and G2019S mutant LRRK2 with IC50 values of 4.76nM and 6.87nM,respectively.CZC-25146 is selective against LRRK2.When treated with 184 different protein kinases and one lipid kinase,CZC-25146 inhibits only five of them with high potency including PLK4,GAK,TNK1,CAMKK2 and PIP4K2C. price>