Catalog name Description price
R-C-437 Telaprevir (VX-950) Trapivir is an effective and selective reversible HCV NS3-4A protein inhibitor, which acts on NS3 protease domain and NS4A cofactor peptide of genotype 1(strain h).Vx-950 is an effective and selective peptide like inhibitor of hepatitis C virus NS3-4A serine protease.It shows excellent antiviral activity in both type 1b HCV replicon cells (50% inhibition concentration [IC50]=354nm) and human fetal liver cells(IC50=280nm) infected with sera from type 1A HCV positive patients. price>
R-C-471 Tasisulam(LY573636) CAS:519055-63-1 LY573636 is a potent anti-tumor agent,which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo.LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. price>
R-C-482 ABT-263(Navitoclax) CAS:923564-51-6 ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki of <1 nmol/L for Bcl-2,Bcl-xL,and Bcl-w).it maintains a high affinity for Bcl-xL,Bcl-2,and Bcl-w,(Ki ≤1 nmol/L),but binds more weakly to Mcl-1 and A1. price>
R-C-483 ABT-737 cas:852808-04-9 ABT-737 is a pan-Bcl-2 inhibitor.IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10μM (Nalm-6,K562 and HL-60). price>
R-C-531 AT-406 cas:1071992-99-8 AT406(SM-406,ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM,1.9 nM,and 5.1 nM,50-to 100-fold higher affinities than the Smac AVPI peptide. price>
R-C-564 RITA (NSC 652287) cas:213261-59-7 RITA(NSC 652287)induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks,and also inhibits MDM2-p53 interaction by targeting p53. price>
R-C-571 Tenovin-1 cas:380315-80-0 Tenovin-1,a p53 activator,protects p53 from MDM2-mediated degradation.Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase(DHODH)inhibitor. price>
R-C-572 Apoptosis Activator 2 cas:79183-19-0 Apoptosis Activator 2 strongly induces caspase-3 activation,PARP cleavage,and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM,inactive to HMEC,PREC,or MCF-10A cells. price>
R-C-573 HA14-1 cas:65673-63-4 HA14-1 is a small,cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action.HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis. price>
R-C-594 ABT-199 cas:1257044-40-8 Venetoclax (ABT-199,GDC-0199)is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays,4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Venetoclax is reported to induce cell growth suppression,apoptosis,cell cycle arrest,and autophagy in triple negative breast cancer MDA-MB-231 cells. price>