QMGFMTSPKHSV-(C Terminal-Ahx-Val-Cit-PABC-MMAE)

QMGFMTSPKHSV-(C Terminal-Ahx-Val-Cit-PABC-MMAE) is a targeted peptide–drug conjugate (PDC) designed for site-specific delivery of a cytotoxic payload.
QMGFMTSPKHSV: a targeting peptide that binds selectively to specific cellular receptors or tumor-associated markers, guiding the conjugate to diseased tissues.
Peptide QMGFMTSPKHSV: N-terminal amino group, k-terminal amino group, and histidine amino group all need to be protected.
Ahx (6-aminohexanoic acid): acts as a flexible spacer, improving the accessibility and stability of the linkage between the peptide and the cleavable linker.
Applications:
Used as a peptide–drug conjugate for targeted cancer therapy, where the peptide enables selective tumor targeting and the Val-Cit-PABC-MMAE module ensures controlled intracellular drug release after enzymatic activation, minimizing systemic toxicity.

msds of QMGFMTSPKHSV-(C Terminal-Ahx-Val-Cit-PABC-MMAE)